Acanthosis nigricans Caused by Nicotinic Acid: Case Report and Review of the Literature

Stals, H; Vercammen, Chris; Peeters, C.; Morren, Ma.

doi:10.1159/000246834

Cited by 34 publications

(19 citation statements)

References 19 publications

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“…Most widely recognized is the association between nicotinic acid [64][65][66] and AN, which typically develops on the abdomen and flexor surfaces of the skin and resolves within 4 to 10 weeks of stopping the medication. 66 Patients with insulin-requiring diabetes may acquire AN as a result of repeated injection of the same sites.…”

Section: Drug-induced Anmentioning

confidence: 99%

“…25 Other medications known to result in the development of AN include oral contraceptives, diethylstilbestrol, 67 heroin, corticosteroids, methyltestosterone, fusidic acid, and hydantoin-like derivatives. 8,65 HISTOPATHOLOGY Cutaneous AN characteristically demonstrates epidermal hyperkeratosis and minimal to mild acanthosis. 4,37 There is an associated upward projection of the dermal papillae into a thinned overlying epidermis; keratinaceous material may fill the regions between the ridges.…”

Section: Drug-induced Anmentioning

confidence: 99%

See 1 more Smart Citation

Juvenile acanthosis nigricans

Sinha¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

120

136

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Section: Drug-induced Anmentioning

confidence: 99%

Section: Drug-induced Anmentioning

confidence: 99%

Juvenile acanthosis nigricans

Sinha¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

120

136

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“…The mechanism of niacin's effect on the macula is unknown (127). Acanthosis nigricans (128) or niacin-induced myopathy (129) belongs to other uncommon adverse effects of niacin. Niacin ER monotherapy has specifically amassed considerable clinical trial data that do not support an increased risk for muscle adverse experiences with niacin monotherapy (130).…”

Section: Other Effectsmentioning

confidence: 99%

Pleiotropic effects of niacin: Current possibilities for its clinical use

et al. 2016

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Niacin was the first hypolipidemic drug to significantly reduce both major cardiovascular events and mortality in patients with cardiovascular disease. Niacin favorably influences all lipoprotein classes, including lipoprotein [a],and belongs to the most potent hypolipidemic drugs for increasing HDL-C. Moreover, niacin causes favorable changes to the qualitative composition of lipoprotein HDL. In addition to its pronounced hypolipidemic action, niacin exerts many other, non-hypolipidemic effects (e.g., antioxidative, anti-inflammatory, antithrombotic), which favorably influence the development and progression of atherosclerosis. These effects are dependent on activation of the specific receptor HCA2. Recent results published by the two large clinical studies, AIM-HIGH and HPS2-THRIVE, have led to the impugnation of niacin's role in future clinical practice. However, due to several methodological flaws in the AIM-HIGH and HPS2-THRIVE studies, the pleiotropic effects of niacin now deserve thorough evaluation. This review summarizes the present and possible future use of niacin in clinical practice in light of its newly recognized pleiotropic effects.

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“…Böbrek nakilli hastalarda da akantozis nigrikans görülme sıklığı artar. Ayrıca oral kontraseptifler, kortikosteroidler, somatotropin, testosteron, triazinat, fusidik asit, fenitoin ve nikotinik asit gibi bazı ilaçlar akantozis nigrikansın ortaya çıkmasına yol açabilir 28,30 . Akantozis nigrikans paraneoplastik olarak da ortaya çıkabilmekle birlikte bu durum sık değildir.…”

Section: Akantozis Nigrikansunclassified

Keratinizasyon bozukluklarının paraneoplastik önemi

Ekinci¹,

Atcı²,

Baykal³

2013

TURKDERM

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ÖzetKeratinizasyon bozukluklarının önemli bölümü konjenital hastalıklar olmakla birlikte edinsel olarak ortaya çıkan keratinizasyon bozuklukları da vardır. Bunların bir çok nedeni arasında sistemik maliniteler de yer alır. Edinsel iktiyoz, Bazex sendromu ve "tripe palms" (işkembe avuç içi) paraneoplastik ilişki oranının yüksek olduğu hastalıklar arasında yer alır. Akantozis nigrikans ise malinite ile birlikte olduğunda çok şiddetli seyreder ve özel klinik görünümlere yol açar. Başka bir nedenle açıklanamayan edinsel palmoplantar keratoderma nadir de olsa paraneoplastik olabilir. Bu hastalıklara erken ve doğru tanı konması malinitelerin erken saptanmasını sağlaması açısından önem taşır. (Türk derm 2013; 47: Özel Sayı 2: 99-102) Anahtar Kelime: Keratinizasyon bozukluğu, malinite, paraneoplazi, edinsel iktiyoz, akantozis nigrikans, akrokeratozis paraneoplastika, palmoplantar keratoderma Sum maryAlthough most of the keratinization disorders are congenital diseases, there are also acquired forms of keratinization disorders. Among their multiple causes systemic malignancies deserve special attention. Acquired ichthyosis, Bazex syndrome and tripe palms are among diseases with highest ratio of paraneoplastic association. On the other hand, acanthosis nigricans has very severe and atypical presentations when associated with malignancy. Acquired palmoplantar keratoderma without any detectable cause could rarely have paraneoplastic origin. The early and correct diagnosis of these diseases is important to disclose the malignancies early. (Turkderm 2013; 47

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Acanthosis nigricans Caused by Nicotinic Acid: Case Report and Review of the Literature

Cited by 34 publications

References 19 publications

Juvenile acanthosis nigricans

Juvenile acanthosis nigricans

Pleiotropic effects of niacin: Current possibilities for its clinical use

Keratinizasyon bozukluklarının paraneoplastik önemi

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