Ação antimicrobiana do gás ozônio em superfícies e na aeromicrobiota

Caetano, Maicon Henrique; Siqueira, João Paulo Zen; Andrade, Denise de; Sousa, Álvaro Francisco Lopes de; Rigotti, Marcelo Alessandro; Diniz, Maiara Oliveira; Almeida, Willian Albuquerque de; Ferreira, Adriano Menis; Almeida, Margarete Teresa Gottardo de

doi:10.37689/acta-ape/2021ao02712

Cited by 1 publication

(2 citation statements)

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“…It is a common cause of opportunistic invasive infections when inhaled, along with being an allergen [8][9]. Due to its high oxidant power ozone (O3) is used for antimicrobial activity during disinfection processes and/or sterilization [10]. Although the mechanisms of its action are not fully understood, O 3 is known to act on cell walls of microorganisms causing the oxidation of glycopeptides, glycoproteins, and amino acids, modifying permeability, and leading to cell lysis.…”

Section: Introductionmentioning

confidence: 99%

“…Ozone is recombined with cytoplasmic elements when it reaches inside the cell, causing oxidation of amino acids and nucleic acids, resulting in cleavage and consequent cell death. Ozone can also collapse cellular enzymatic activity due to its action on the sulfhydryl compounds of enzymes and alter the purine and pyrimidine bases of nucleic acids [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Effect of ozone gas on cultures of Candida albicans and Aspergillus fumigatus: evaluation of two ozonation devices

Caetano,

Menis Ferreira,

De Andrade

et al. 2024

J Infect Dev Ctries

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Introduction: Candida albicans and Aspergillus fumigatus are two important agents of Healthcare-associated infections. This study aimed to evaluate the antifungal activity of ozone (O3) gas produced by two commercial devices against cultures of these two species. Methodology: Sterile plastic plates were inoculated with C. albicans and A. fumigatus and placed on a countertop at three distances (30 cm, 1 m, and 2 m) and three positions in relation to the wall (near, middle, and away), considering the source of O3. Plates were exposed to O3 for one hour and incubated. After incubation, the counting of colony-forming units was performed. As a control, an inoculated plate was incubated, without being exposed to O3. Tests were carried out with two different devices (namely, Mod.I and Mod.II), with the air conditioner on and off, in triplicate. Results: Both devices showed antifungal activity. Mod. I presented better results, due to a higher flow rate. The best activity was on plates at 30 cm, middle position. Contrarily, on plates at 2m, near the wall, the inhibition activity was lower. The best results were obtained with the air conditioner off. Candida albicans was more sensitive to O3 than A. fumigatus. Conclusions: This method of decontamination by O3 gas shows potential due to its fast and easy execution. The establishment of new protocols for hygiene and hospital disinfection using this approach should be considered, which may reduce environmental contamination by fungi and, consequently, the burden of fungal infections.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%