Acaricidal Activities of Extracts of Stellera chamaejasme Against Tetranychus viennensis (Acari: Tetranychidae)

Shi, Guanglu; Liu, S. Q.; Hui, Cao; Zhao, Lei; Li, J.; Li, S. Y.

doi:10.1093/jee/97.6.1912

Cited by 19 publications

(11 citation statements)

References 4 publications

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“…Compositae) and Tanacetum vulgare Linné were toxic to the twospotted spider mite, Tetranychus urticae Koch (Chiasson et al 2001). Extracts from Azadirachta indica A. Juss and Stellera chamaejasma L. have strong acaricidal activity (Sundaram and Sloane 1995, Williams and Mansingh 1996, Shi et al 2004. Erler and Tunç (2005) tested eight monoterpenoids from plant essential oils for bioactivity to T. cinnabarinus.…”

Section: Abstract Green Walnut Husks Methyl Palmitate Acaricidal Amentioning

confidence: 99%

Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks

Wang¹,

Wang²,

Shen³

et al. 2009

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Walnut, Juglans regia L., is known for its insecticidal activities to a range of herbivores and microbes. Isolation and identification of bioactive compounds from walnut is a potential approach for the development of new pesticides. Laboratory experiments were carried out to investigate the acaricidal activities of green husk extracts of walnut. Bioassay-guided fractionation of petroleum-ether extracts of walnut led to the identification of a common plant-borne fatty acid ester, methyl palmitate (MP), which produced strong acaricidal activity (62.8% mortality) at 1 mg/ml at 24 h. The structure of MP was characterized with infrared spectrum and NMR, and the identification of MP confirmed using an authentic standard on high-performance liquid chromatography. Based on a slide dip bioassay, 10 mg/ml MP provided 97.9% mortality against adults of Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae), whereas mortality against eggs was much lower (57.2%).

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Section: Abstract Green Walnut Husks Methyl Palmitate Acaricidal Amentioning

confidence: 99%

Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks

Wang¹,

Wang²,

Shen³

et al. 2009

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“…Different root extracts of Stellera chamaejasme showed antimicrobial activity against several microorganisms, and particularly against three bacteria, and twelve phytopathogenic fungi (Lin et al 2009;Bai et al 2012). Other studies have reported pesticidal and acaricidal activity (Wang et al 2002;Shi et al 2004). Daphne bholua is used to treat intestinal worms in Sikkim Himalaya (Panda and Misra 2010: 186), it showed antibacterial, antifungal, antiprotozoal, and antiviral activity (Goel et al 2002).…”

Section: Recent Researchmentioning

confidence: 99%

Tibetan Printing: Comparison, Continuities, and Change

Diemberger¹,

Ehrhard²,

Kornicki³

2016

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“…Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica Stellera chamaejasme L. (Thymelaeaceae) is a toxic perennial herb. Its root is known as Langdu and is described in the Chinese Pharmacopoeia [1] as having antiviral [2,3], antitumor [4], antibacterial [5], immunomodulatory [6], and insecticidal effects [7,8]. The use of Langdu along with various clinically prescribed drugs may result in a herb-drug interaction or Langdu toxicity [9].…”

Section: Intmentioning

confidence: 99%

“…The incubation conditions were similar to those used with HLMs except that the CYP content was 50 pmol CYP×mL −1 or the UGT concentration was 0.5 mg protein × mL −1 . Eleven concentrations of chamaechromone (2,5,10,25,50,100,200, 500, 750, 1000, and 2000 µM) were incubated in triplicate with HLM samples, hCYPs, or hUGTs to obtain the kinetic profiles of chamaechromone metabolism. Quantitative analysis via LC-MS was performed as described previously [12].…”

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Metabolism of Chamaechromone In Vitro with Human Liver Microsomes and Recombinant Human Drug-Metabolizing Enzymes

et al. 2014

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Chamaechromone is a major component in the dried roots of Stellera chamaejasme with antihepatitis B virus and insecticidal activity. In this study, metabolic profiles of chamaechromone were investigated in human liver microsomes. One monohydroxide and two monoglucuronides of chamaechromone were identified. The enzyme kinetics for both hydroxylation and glucuronidation were fitted to the Michaelis-Menten equation. The hydroxylation of chamaechromone was inhibited by α-naphthoflavone, and predominantly catalyzed by recombinant human cytochrome P450 1A2, whereas the glucuronidation was inhibited by quercetin, 1-naphthol, and fluconazole, and mainly catalyzed by recombinant human UDP-glucuronosyltransferase 1A3, 1A7, 1A9, and 2B7. Key wordsStellera chamaejasme · Thymelaeaceae · chamaechromone · metabolite · in vitro · human liver microsomes · recombinant human enzymes Abbreviations ! CL int : intrinsic clearance DDI: drug-drug interaction hCYP: human cytochrome P450 HLMs: human liver microsomes hUGT: human UDP-glucuronosyltransferase K m : Michaelis constant UDPGA: UDP-glucuronic acid UPLC Q-TOF MS: ultra-performance liquid chromatography quadrupole-time-of-flight mass spectrometry V max : maximal velocity of formation Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica Stellera chamaejasme L. (Thymelaeaceae) is a toxic perennial herb. Its root is known as Langdu and is described in the Chinese Pharmacopoeia [1] as having antiviral [2, 3], antitumor [4], antibacterial [5], immunomodulatory [6], and insecticidal effects [7, 8]. The use of Langdu along with various clinically prescribed drugs may result in a herb-drug interaction or Langdu toxicity [9]. Chamaechromone, a biflavone, is one of the major active constituents of the dried roots of S. chamaejasme [10]. The range of chamaechromoneʼs biological effects, such as its anti-HBV effect and insecticidal activity [2, 7], may explain the widespread use of Langdu. The pathways of biflavone metabolism are relatively limited compared to monomeric flavones [11]. Few studies have reported the metabolic characteristics of chamaechromone in human liver microsomes (HLMs). We estimated the oral bioavailability of chamaechromone in rats to be 8.9 % in our previous study [12]. Our follow-up study further established the metabolites of chamaechromone in the rat and in the rat liver S9 fraction [13]. However, humans and animals may display markedly different metabolic profiles with regard to the composition of different isoforms, and the expression and catalytic activities of drug-metabolizing enzymes [14]. Furthermore, HLMs and recombinant enzymes are useful in vitro tools for the prediction of drug-metabolism pathways in vivo in humans and for the identification of specific enzymes involved in these pathways. They also offer valuable insights into potential clinical drug-drug interactions [15]. They may also potentially reduce the use of animals and provide an easy drug-metabolizing enzyme assay protocol. In view of these advantages...

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Acaricidal Activities of Extracts of Stellera chamaejasme Against Tetranychus viennensis (Acari: Tetranychidae)

Cited by 19 publications

References 4 publications

Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks

Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks

Tibetan Printing: Comparison, Continuities, and Change

Metabolism of Chamaechromone In Vitro with Human Liver Microsomes and Recombinant Human Drug-Metabolizing Enzymes

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