Acaricidal Activity against Panonychus citri and Active Ingredient of the Mangrove Plant Cerbera manghas

Abstract

Cerbera manghas is a mangrove plant which possesses comprehensive biological activities. A great deal of research has been undertaken on the chemical constituents and medical functions of C. manghas; insecticidal and antifungal activities have also been reported, but the acaricidal activity has not been studied. In our study, the acaricidal activity and active substances of C. manghas were investigated using a spray method, which showed that the methanol extracts of the fruit, twigs and leaves exhibited contact activity against female adults of Panonychus citri, with LC50 values at 24 h of 3.39 g L−1, 4.09 g L−1 and 4.11 g L−1, respectively. An acaricidal compound was isolated from C. manghas by an activity-guided isolation method, and identified as (-)-17β-neriifolin, which is a cardiac glycoside. (-)-17β-Neriifolin revealed high contact activity against female adults, nymphae, larvae and eggs of P. citri, with LC50 values at 24 h of 0.28 g L−1, 0.29 g L−1, 0.28 g L−1 and 1.45 g L−1, respectively.

Marine natural products

“…Further investigation of previously reported mangrove MNPs has identied avicequinone C (Avicennia marina) 918 as a 5a-reductase-type 1 inhibitor, 919 catunaregin (Micromelum falcatum) 920 as an angiogenesis inhibitor, 921 the cardiac glycoside neriifolin (Cerbera manghas) 922 as the acaricidal component of Panonychus citri, 923 and that leaf extracts and puried components of Avicennia marina exhibit antibacterial activity with relevance to urinary tract infections. 924 Finally, a new biomimetic synthesis 925 and a structure-activity relationship study of the protein tyrosine phosphatase 1B inhibiting properties 926 of the unusual dimeric alkylbutenolide paracaseolide A (Sonneratia paracaseolaris) 927 have been reported.…”

Investigation of the Inhibitory Effects of Mangrove Leaves and Analysis of Their Active Components on Phaeocystis globosa during Different Stages of Leaf Age

“…This is because, in the present study, the chemical components of the leaves were all originated from mangrove plants and extracted with water [ 58 ]. However, the majority of the components reported in the previous studies were of low polarity or semipolar substances extracted with petroleum ether or ethyl acetate following initial extraction by methanol and/or ethanol [ 59 , 60 ].…”

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

“…Various notable compounds are successfully identified from the extract of mangrove fruit. The eminent compound, such as (-)-17 β -neriifolin, a cardiac glycoside, is found in the extract of Cerbera manghas with excellent heart stimulation function, effective in curing acute heart failure, at the same time show antiestrogenic, antiproliferative, and anticancer activities [ 55 ]. The fruit of B. gymnorrhiza contains isopimaradiene and 4-(2-aminopropyl) phenol.…”

“…The active compounds with applications as larvicidals are phenols, tannins, saponins, flavonoids, and quinones [ 181 ]. The fruit of C. manghas shows acaricidal activity against female adults of Panonychus citri (LC 50 = 3.39 g/L) [ 55 ]. The mangrove forest also has a remarkable area containing pollutants, including solid particles such as micro/nanoplastics [ 182 ], organic pollutants (e.g., PAHs, PCBs, and other POPs), and metals [ 183 , 184 , 185 , 186 ].…”