Acari is an important group that include many economically important agricultural and veterinary pest species. The most preferred method for manage these pests is chemical control. However, the ability of quick resistance development of particularly Tetranychus urticae Koch and other Acari causes to chemical control failures in the field conditions. Moreover, T. urticae is the most resistant arthropod species to chemicals and called as "resistance champion". In order to prevent these failures, mechanism of resistance must be understood. In this review, resistance mechanisms in economically important species that belongs to Acari subclass have been elucidated in the light of current researchs. In this way, it is aimed to make chemical control of mites more accurate and conscious, and also to design proper resistance management programs.