Accelerated Aging Mediates the Associations of Unhealthy Lifestyles with Cardiovascular Disease, Cancer, and Mortality: Two Large Prospective Cohort Studies

Cao, Xingqi; Zhang, Jingyun; Fu, Jinjing; Mohedaner, Mayila; Danzengzhuoga,; X, Sun; Yang, Gan; Yang, Zhenqing; Kuo, Chia‐Ling; Chen, Xi; Cohen, Alan A.; Liu, Zuyun

doi:10.1101/2022.05.18.22275184

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…Numerous previous studies have revealed the longitudinal evolution of physical and mental ability in the elderly population, highlighting the fact that abilities of the elderly gradually decline over time. However, it is not just a simple linear relationship [45]. Over time, many of the abilities of the elderly population will decline more rapidly, and the impact of such a decline will gradually increase [46,47].…”

Section: Discussionmentioning

confidence: 99%

Value shift in response to aging: A longitudinal study based on healthy aging

Shen,

Cheng,

Sang

et al. 2024

Preprint

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Objective Healthy aging is considered an effective way to deal with the challenges of aging. Intrinsic capacity(IC) and functional ability (FA) are the key elements of this concept. However, the relationship between the two has not been explored in detail. Methods A theoretical model was constructed by analyzing the concept of “health aging quantification.” A national database (China Health and Retirement Longitudinal Study, CHARLS) was used as the data source for the study. A range of physical and mental measures were employed to construct intrinsic abilities using factor analysis, and a measure of disability was used as a proxy for FA. Descriptive and regression analyses were also conducted to preliminarily assess the distribution of the variables on the IC). This study used cross-lagged models to examine structural and effect differences between IC and FA in the longitudinal manner, along with mediation analysis to analyze the mechanism of the two. Results IC showed normal distribution and an increasing trend in education and income. In the structural analysis, IC and FA indicate significant cross-lagged effects in the longitudinal direction. The effect of IC on FA is also greater than that of FA on IC; such an effect also tends to intensify over time. Furthermore, multimorbidity mediates the effect of IC on FA, but the mediating effect is not very large. Finally, social participation did not significantly mediate the effect of FA on IC. Conclusion The study provides novel insights into the evolution of disability, in which the discovery of the disease is only a process of the outcome of disability. This suggests that policymakers should not only focus on identifying a disease, but also on assessing, maintaining, and providing intervention before the disease. The authorities should also promote the implementation of people-centered rather than disease-centered measures in the health delivery system to achieve value transformation.

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Section: Discussionmentioning

confidence: 99%

Value shift in response to aging: A longitudinal study based on healthy aging

Shen,

Cheng,

Sang

et al. 2024

Preprint

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“…α-Klotho is an anti-aging protein primarily produced in the kidneys [ 7 , 8 , 9 ]. A previous study has shown that Phenotypic Age Acceleration, a measure of accelerated aging, partially mediates the association of unhealthy lifestyles, including an unhealthy diet, with adverse health outcomes, such as cardiovascular disease, cancer, and mortality, in populations from the UK and the US [ 33 ]. Our findings suggest an anti-aging mechanism underlying the relationship between a healthy diet and enhanced kidney function through the involvement of serum α-Klotho, which plays a crucial role in preserving kidney health by regulating calcium and phosphate metabolisms, inhibiting renal fibrosis, reducing oxidative stress, and promoting anti-inflammatory effects [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Anti-Aging Protein α-Klotho Mediates the Association between Diet Quality and Kidney Function

Cai

et al. 2023

Nutrients

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Adherence to healthy dietary patterns is associated with a reduced risk of kidney dysfunction. Nevertheless, the age-related mechanisms that underpin the relationship between diet and kidney function remain undetermined. This study aimed to investigate the mediating role of serum α-Klotho, an anti-aging protein, in the link between a healthy diet and kidney function. A cross-sectional study was conducted on a cohort of 12,817 individuals aged between 40 and 79 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. For each participant, the Healthy Eating Index 2015 (HEI-2015) score was calculated as a measure of a healthy dietary pattern. Creatinine-based estimated glomerular filtration rate (eGFR) was used to assess kidney function. Multivariable regression models were used to analyze the association between the standardized HEI-2015 score and eGFR after adjusting for potential confounders. Causal mediation analysis was performed to assess whether serum α-Klotho influenced this association. The mean (±SD) eGFR of all individuals was 86.8 ± 19.8 mL/min per 1.73 m2. A high standardized HEI-2015 score was associated with a high eGFR (β [95% CI], 0.94 [0.64–1.23]; p < 0.001). The mediation analysis revealed that serum α-Klotho accounted for 5.6–10.5% of the association of standardized overall HEI-2015 score, total fruits, whole fruits, greens and beans, and whole grain with eGFR in the NHANES. According to the results from the subgroup analysis, serum α-Klotho exerted a mediating effect in the participants aged 60–79 years and in males. A healthy diet may promote kidney function by up-regulating serum anti-aging α-Klotho. This novel pathway suggests important implications for dietary recommendations and kidney health.

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“…In the above equation, CA represents the chronological age; x represents the value of biomarker j; q, k, and s represent parameters when biomarker j is regressed on CA; and sBA represents a scaling factor equal to the square root of the variance in chronological age explained by the biomarker set. Furthermore, we calculated the BioAgeAccel (20) by estimating the differences in the biological and chronological age (21). A negative BioAgeAccel value indicated a lower biological age.…”

Section: Measurement Of Biological Agementioning

confidence: 99%

Association between cardiometabolic index and biological ageing among adults: a population-based study

Liu,

Lin

2024

Preprint

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Background Cardiovascular health (CVH) is closely associated with ageing. This study aimed to investigate the association between cardiometabolic index (CMI), a novel indicator of cardiometabolic status, and biological ageing. Methods Cross-sectional data were obtained from participants with comprehensive CMI and biological age data in the National Health and Nutrition Examination Survey from 2011 to 2018. Biological age acceleration (BioAgeAccel) was calculated as an ageing index using eight biomarkers. Weighted multivariable regression, sensitivity analysis, and smoothing curve fitting were performed to explore the independent association between CMI and the acceleration of biological age. Subgroup and interaction analyses were performed to investigate whether this association was consistent across populations. Results In 4282 subjects ≥ 20 years of age, there was a positive relationship between CMI and biological age. Each unit increase in CMI was associated with a 16% increase in biological age acceleration [1.16 (1.02, 1.31)] in the fully adjusted models. The participants in the highest CMI quartile had a 149% higher BioAgeAccel [2.49 (2.15, 2.83)] than those in the lowest CMI quartile. In stratified studies, the positive correlation between CMI and biological age acceleration remained consistent across strata. This positive correlation was stronger in female populations. Conclusions CMI is positively correlated with biological ageing in adults in the United States. Encouraging lower CMI levels may be advantageous in alleviating ageing.

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Accelerated Aging Mediates the Associations of Unhealthy Lifestyles with Cardiovascular Disease, Cancer, and Mortality: Two Large Prospective Cohort Studies

Cited by 6 publications

References 59 publications

Value shift in response to aging: A longitudinal study based on healthy aging

Value shift in response to aging: A longitudinal study based on healthy aging

Serum Anti-Aging Protein α-Klotho Mediates the Association between Diet Quality and Kidney Function

Association between cardiometabolic index and biological ageing among adults: a population-based study

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