Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

Stavnsbjerg, Camilla; Christensen, Esben; Münter, Rasmus; Henriksen, Jonas Rosager; Fach, Matthias; Parhamifar, Ladan; Christensen, Camilla L.; Kjær, Andreas; Hansen, Anders Elias; Andresen, Thomas Lars

doi:10.1016/j.jconrel.2021.12.033

Cited by 30 publications

(26 citation statements)

References 40 publications

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“…443 According to a recent report, PEGylated liposomes containing TLR agonists induced hypersensitivity reaction upon multiple dosing, which may be attributed to the generation of anti-PEG IgGs. 444 This journal is © The Royal Society of Chemistry 2023 Chem. Soc.…”

Section: Remission Of the Therapy-induced Toxicity Issuementioning

confidence: 99%

“…The immunotoxicity of PEGylated liposomes used as a vaccine was recently revealed, 452,453 including the anti-PEG IgG-induced hypersensitivity reaction. 444 However, there are very few reports on thorough characterization of immunogenicity and immunotoxicity of polymer-, protein-, or inorganic-based nanocarriers. The standardized characterization methods should be established to accelerate the translation of nanomedicines for clinical trials.…”

Section: Summary Of the Challenging Issues For Radioimmunotherapymentioning

confidence: 99%

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Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Luo

Zhang

et al. 2023

Chem. Soc. Rev.

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Section: Remission Of the Therapy-induced Toxicity Issuementioning

confidence: 99%

Section: Summary Of the Challenging Issues For Radioimmunotherapymentioning

confidence: 99%

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Luo

Zhang

et al. 2023

Chem. Soc. Rev.

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“…Hence, systemic effects remain a challenge that needs to be addressed by various in vitro toxicology assessment methods. Some liposomal drug formulations are also associated with the induction of complement pathways and hypersensitivity reactions in addition to increased blood clearance [ 127 , 128 ]. Overall, the full potential of liposome-based immunotherapeutics can be achieved through careful assessment and understanding of various formulations of liposomes with the cellular and immune machinery.…”

Section: Pharmacokinetics and Toxicology Of Nanomaterials Repertoire ...mentioning

confidence: 99%

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Farhana

2023

IJMS

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Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a considerable increase in survival rates. Despite its promising outcomes, current immunotherapy is still limited in its efficacy. Newer modalities are now being explored, and significant progress is made by integrating cancer immunotherapy with modular nanotechnology platforms to enhance its therapeutic efficacy and diagnostics. Research on targeting skin cancers with nanomaterial-based techniques has been much more recent than other cancers. Current investigations using nanomaterial-mediated targeting of nonmelanoma and melanoma cancers are directed at augmenting drug delivery and immunomodulation of skin cancers to induce a robust anticancer response and minimize toxic effects. Many novel nanomaterial formulations are being discovered, and clinical trials are underway to explore their efficacy in targeting skin cancers through functionalization or drug encapsulation. The focus of this review rivets on theranostic nanomaterials that can modulate immune mechanisms toward protective, therapeutic, or diagnostic approaches for skin cancers. The recent breakthroughs in nanomaterial-based immunotherapeutic modulation of skin cancer types and diagnostic potentials in personalized immunotherapies are discussed.

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“…The purpose of polyethylene glycol modification is to eliminate the cytotoxicity of CTAB 81 and give AuNRs electronegativity to bind electrostatically to dipalmitoylphosphatidylcholine (DPPC). 82 In this liposome, AuNRs could be present on the inner and outer hydrophilic sides of the membrane and jointly mediate the photothermal effect. After continuous irradiation with 785 nm NIR light at a power density of 1.35 W/cm 2 for 5 min, the cumulative release rate of liposomes for the drug model lactalbumin was approximately 40% higher than that of the control without light at the 15th minute.…”

Section: Photoresponsive Liposomesmentioning

confidence: 99%

“…AuNRs were mainly obtained by water-soluble binding of cetyltrimethylammonium bromide (CTAB) to chloroauric acid and reduction of ascorbic acid. The purpose of polyethylene glycol modification is to eliminate the cytotoxicity of CTAB and give AuNRs electronegativity to bind electrostatically to dipalmitoylphosphatidylcholine (DPPC) . In this liposome, AuNRs could be present on the inner and outer hydrophilic sides of the membrane and jointly mediate the photothermal effect.…”

Section: Photoresponsive Liposomes Based On Au Nanoparticlesmentioning

confidence: 99%

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

Pan

et al. 2022

ACS Appl. Nano Mater.

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Photoresponsive liposomes are controlled-release liposomes modified by photoresponsive materials. They use light with high spatial and temporal precision as a means of regulation. After excitation by light at appropriate wavelengths, photoresponsive liposomes can influence the permeability of phospholipid bilayers through the photothermal or photoisomerization effect of photoresponsive materials. The photothermal effect causes the phospholipid layer to become dispersed by local heating, and the photoisomerization effect modulates the release behavior by establishing permeation channels on the phospholipid layer through changes in the dipole moments of azobenzene derivatives. Currently, photoresponsive liposomes are widely used as a cutting-edge strategy for nanomedicine. In this paper, three types of photoresponsive liposomes based on organic photosensitizers, Au nanoparticles, and azobenzene derivatives with abundant research reports were introduced based on the differences in the photoresponse principles and forms of different photoresponsive materials. This review aims to reflect the differences in the structures, properties, photoresponsive materials, and principles of action of different photoresponsive liposomes. Moreover, this work outlines the current status of their application in the field of nanomedicine.

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Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

Cited by 30 publications

References 40 publications

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

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