Accelerated corpus callosum development in prematurity predicts improved outcome

Thompson, Deanne K.; Lee, Katherine J.; Bijnen, Loeka van; Leemans, Alexander; Pascoe, Leona; Scratch, Shannon E.; Cheong, Jeanie L.Y.; Egan, Gary F.; Inder, Terrie E.; Doyle, Lex W.; Anderson, Peter J.

doi:10.1002/hbm.22874

Cited by 30 publications

(40 citation statements)

References 70 publications

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“…Studies also show abnormal microstructural organization in a number of white matter pathways in the preterm brain, including the internal capsule, external capsule, inferior fronto-occipital fasciculus, uncinate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, centrum semiovale (Nagy et al , 2003, Skranes et al , 2007, Constable et al , 2008, Mullen et al , 2011, Jo et al , 2012, Lee et al , 2013, Groeschel et al , 2014), and corpus callosum (Thompson et al , 2014), which has previously been reported for the current cohort. dMRI studies exploring structure-function associations in preterm cohorts have found that alterations in white matter microstructure are related to motor deficits (Skranes et al , 2007, Counsell et al , 2008, Rose et al , 2009, Thompson et al , 2012, van Kooij et al , 2012, Northam et al , 2012 ), neurosensory impairments (Bassi et al , 2008, Berman et al , 2009, Reiman et al , 2009, Glass et al , 2010, Groppo et al , 2014), and behavioral dysfunction (Nagy et al , 2003, Skranes et al , 2007, Rogers et al , 2012).…”

Section: 1 Introductionsupporting

confidence: 85%

“…Finally, to identify the corpus callosum a single ROI was traced on the mid-sagittal slice of the structural T1 scan and overlaid on the diffusion image as previously reported (Thompson et al , 2014) (Fig. 4).…”

Section: 2 Materials and Methodsmentioning

confidence: 99%

“…While the literature on dMRI and prematurity is limited, some studies have found reduced fractional anisotropy (Anjari et al , 2007) and increased axial, radial, and mean diffusivity in the white matter of VPT infants, children and adolescents compared with term-born controls (Bonifacio et al , 2010, Feldman et al , 2012, Thompson et al , 2014). Studies also show abnormal microstructural organization in a number of white matter pathways in the preterm brain, including the internal capsule, external capsule, inferior fronto-occipital fasciculus, uncinate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, centrum semiovale (Nagy et al , 2003, Skranes et al , 2007, Constable et al , 2008, Mullen et al , 2011, Jo et al , 2012, Lee et al , 2013, Groeschel et al , 2014), and corpus callosum (Thompson et al , 2014), which has previously been reported for the current cohort.…”

Section: 1 Introductionmentioning

confidence: 99%

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White matter abnormalities and impaired attention abilities in children born very preterm

et al. 2016

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While attention impairments are commonly observed in very preterm (<32 weeks’ gestational age) children, neuroanatomical correlates of these difficulties are unclear. We aimed to determine whether the microstructural organization of key white matter tracts thought to be involved in attention (cingulum bundle, superior longitudinal fasciculi, reticular activating system, and corpus callosum) were altered in very preterm children compared with term-born controls. We also aimed to determine whether alterations in microstructural organization of these tracts were associated with attention functioning in very preterm children. One hundred and forty-nine very preterm children and 36 term-born controls underwent neuroimaging and assessment of their attention abilities at 7 years. Constrained spherical deconvolution and probabilistic tractography was used to identify the key white matter tracts. Altered microstructural organization and reduced tract volume within reticular activating system and corpus callosum were found in the very preterm group compared with the control group. Diffusion and volume changes in the cingulum bundle, superior longitudinal fasciculi, reticular activating system, and corpus callosum were related to variations in attention functioning in the very preterm children. These findings emphasize that white matter tract integrity is associated with later attentional abilities in very preterm children.

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Section: 1 Introductionsupporting

confidence: 85%

Section: 2 Materials and Methodsmentioning

confidence: 99%

Section: 1 Introductionmentioning

confidence: 99%

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White matter abnormalities and impaired attention abilities in children born very preterm

et al. 2016

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“…Previous studies of WM structure have tended to focus on individual WM regions using methods such as tractography or regions of interest. These previous studies have shown that VP children have altered microstructure in specific tracts such as the corpus callosum, corticospinal tracts or optic radiations, which often correlate with neurodevelopmental delays (Pannek et al, 2014b; Thompson et al, 2015). However, in contrast to previous regional studies, the graph theory method used in the current study enabled us to provide novel evidence that the complexity of the whole brain connectome is altered in VP children.…”

Section: Discussionmentioning

confidence: 97%

Structural connectivity relates to perinatal factors and functional impairment at 7 years in children born very preterm

et al. 2016

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Objective To use structural connectivity to (1) compare brain networks between typically and atypically developing (very preterm) children, (2) explore associations between potential perinatal developmental disturbances and brain networks, and (3) describe associations between brain networks and functional impairments in very preterm children. Methods 26 full-term and 107 very preterm 7-year-old children (born <30 weeks’ gestational age and/or <1250 g) underwent T1- and diffusion-weighted imaging. Global white matter fiber networks were produced using 80 cortical and subcortical nodes, and edges created using constrained spherical deconvolution-based tractography. Global graph theory metrics were analysed, and regional networks were identified using network-based statistics. Cognitive and motor function were assessed at 7 years of age. Results Compared with full-term children, very preterm children had reduced density, lower global efficiency and higher local efficiency. Those with lower gestational age at birth, infection or higher neonatal brain abnormality score had reduced connectivity. Reduced connectivity within a widespread network was predictive of impaired IQ, while reduced connectivity within the right parietal and temporal lobes was associated with motor impairment in very preterm children. Conclusions This study utilized an innovative structural connectivity pipeline to reveal that children born very preterm have less connected and less complex brain networks compared with typically developing term-born children. Adverse perinatal factors led to disturbances in white matter connectivity, which in turn are associated with impaired functional outcomes, highlighting novel structure-function relationships.

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“…Recent reports in school-age children revealed fractional anisotropy in the corpus callosum and fractional anisotropy-weighted global efficiency of the entire brain network to be related to measures of intelligence and mathematical skills in both healthy children born at term and preterm. 8,19,20 The latter connectivity measure reflects how well the white matter framework is able to support global information transfer across different sites of the brain. These studies had a cross-sectional design, measuring both DWI and cognitive measures in childhood.…”

Section: Discussionmentioning

confidence: 99%

White matter maturation in the neonatal brain is predictive of school age cognitive capacities in children born very preterm

Keunen

Benders

Leemans

et al. 2017

Develop Med Child Neuro

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Accelerated corpus callosum development in prematurity predicts improved outcome

Cited by 30 publications

References 70 publications

White matter abnormalities and impaired attention abilities in children born very preterm

White matter abnormalities and impaired attention abilities in children born very preterm

Structural connectivity relates to perinatal factors and functional impairment at 7 years in children born very preterm

White matter maturation in the neonatal brain is predictive of school age cognitive capacities in children born very preterm

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