Accelerated degeneration of allografts in the first two years of life

Yankah, A. C.; Alexi-Meskhishvili, V.; Weng, Yuguo; Schorn, K.; Lange, Peter; Hetzer, Roland

doi:10.1016/0003-4975(95)00289-w

Cited by 87 publications

(40 citation statements)

References 10 publications

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“…For example, the content of mineralized calcium in native porcine aortic walls and heart valve leaflets before implantation was 0.8±0.6 and 0.6±0.6 mg/g dry tissue, respectively, while 2 months after implantation the corresponding value were 69±10 and 0.6±0.6 mg/g dry tissue. This is in line with clinical data indicating significant calcification of aortic walls and with the absence of calcification of the leaflets in orthotopic transplantation of human heart valve allografts [16], which prompts using the model of subcutaneous implantation to rats for studies of calcinosis of allo-and xenotransplants.…”

Section: Resultssupporting

confidence: 58%

Improving biocompatibility of heart valve and vascular transplants by their devitalization and repopulation by recipient cells

et al. 2006

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Inoculation of cells derived from the aorta of Wistar rats on devitalized porcine aortic walls 2-4-fold reduced their calcinosis after subcutaneous implantation to Wistar rats. Inoculation of Wistar rat bone marrow mesenchymal cells selected by adhesion activity did not reduce tissue calcinosis. The results indicate good prospects of repopulation of devitalized heart valve and vessel transplants by recipient vascular cells for reducing transplant calcinosis and improvement of their biocompatibility.

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Section: Resultssupporting

confidence: 58%

Improving biocompatibility of heart valve and vascular transplants by their devitalization and repopulation by recipient cells

et al. 2006

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“…Authors agree broadly that homograft durability and availability are not ideal, especially in small patients [17][18][19][20].…”

Section: Discussionmentioning

confidence: 91%

Evaluation of 188 consecutive homografts implanted in pulmonary position after 20 years☆☆☆

Boethig

Goerler

Westhoff-Bleck

et al. 2007

European Journal of Cardio-Thoracic Surgery

100

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“…Yankah et al found that homografts placed in younger patients were prone to early degeneration, as determined by measuring their immunological responses. 13 In his review of articles on the early deterioration of valved homografts, Stark identified 3 risk factors: young age, small-sized homograft, and immunological response. 33 Recently, blood type mismatch has been thought to provoke the immunological response and result…”

Section: Discussionmentioning

confidence: 99%