Accelerated Dissolution Method to Facilitate In Vitro Evaluation of Risperidone-Containing Microspheres

Ma, Cheng; Fu, Han; Huang, Zhengwei; Ma, Xiangyu; Liu, Yang; Wang, Wenhua; Wu, Mingjun; Zhang, Xuejuan; Huang, Ying; Wu, Chuanbin

doi:10.14227/dt260219p48

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…In order to explore the inherent stability of the prepared Ticagrelor sustained-release microspheres, we took an appropriate amount of prepared microspheres and investigated the influence of temperature, humidity and light on the three unilateral factors [ 11 ]. Each test was repeated 3 times.…”

Section: Experimental Materialsmentioning

confidence: 99%

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection

Hao

Jiang

Zhang

et al. 2021

Designed Monomers and Polymers

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The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate. Ticagrelor microspheres were prepared successfully with average diameter of 7.31 µm, drug loading of 12.49 ± 0.32% and EE up to 79.09 ± 1.69%. In the release medium of PH7.4 PBS, the microspheres showed good drug release behavior in vitro. In vivo release results also showed that the sustained-release microspheres could effectively control drug release in vivo and maintain a relatively stable blood drug concentration for about 2 weeks. The results indicate that Ticagrelor sustained-release microspheres can be used for long-term treatment of acute coronary syndrome.

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Section: Experimental Materialsmentioning

confidence: 99%

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection

Hao

Jiang

Zhang

et al. 2021

Designed Monomers and Polymers

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An Assessment of Occasional Bio-Inequivalence for BCS1 and BCS3 Drugs: What are the Underlying Reasons?

Butler

Augustijns

2022

Journal of Pharmaceutical Sciences

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Bilayer fixed-dose Combination Tablet for Curcumin Microparticles and Piroxicam and I N Vitro Evaluation

et al. 2022

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Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & methods: The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer. Results: SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. In vitro studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles. Conclusion: Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation.

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Accelerated Dissolution Method to Facilitate In Vitro Evaluation of Risperidone-Containing Microspheres

Abstract: Self-prepared 30% drug-loading risperidone-containing MS with PLGA as matrix was fabricated by UPPS. The

Cited by 3 publications

References 28 publications

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection

An Assessment of Occasional Bio-Inequivalence for BCS1 and BCS3 Drugs: What are the Underlying Reasons?

Bilayer fixed-dose Combination Tablet for Curcumin Microparticles and Piroxicam and I N Vitro Evaluation

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