Accelerated healing of full thickness dermal wounds by macroporous waterborne polyurethane-chitosan hydrogel scaffolds

Bankoti, Kamakshi; Rameshbabu, Arun Prabhu; Datta, Sayanti; Maity, Pintu; Goswami, Piyali; Datta, Pallab; Ghosh, Sudip Kumar; Mitra, Analava

doi:10.1016/j.msec.2017.07.018

Cited by 78 publications

(28 citation statements)

References 44 publications

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“…Adsorption of serum-derived proteins by the wound dressing causes delay in the wound healing process due to increase adherence of dressings leading to trauma and acute pain during dressing changes. Therefore, lower protein adsorption by wound care films is preferred for rapid healing process 23 . For this reason, the composite films were subjected to protein adsorption study using bovine serum albumin.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Lauroyl Grafted Alginate-Psyllium Husk Gel Composite Film with Enhanced Physicochemical, Mechanical and Antimicrobial Properties

Fernandes

Acharya

Bhatt

2018

Sci Rep

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In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized. This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gel-alginate for its mechanical and physicochemical properties. Additionally, the composite film has also been evaluated for protein adsorption and antimicrobial property to verify its utility in biomedical applications. The results showed that the composite films have enhanced physicochemical and mechanical properties. The film produced better swelling characteristic and lower protein adsorption property indicating the usefulness of the film in wound care dressing, particularly for low suppurating wounds. Incorporation of the synthesised glycolipid derivative also imparts antimicrobial activity to the composite film. Therefore, the developed film is capable of sustaining the microbial contamination during the storage and also valuable in the biomedical utility including wound dressings.

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Section: Resultsmentioning

confidence: 99%

Preparation of Lauroyl Grafted Alginate-Psyllium Husk Gel Composite Film with Enhanced Physicochemical, Mechanical and Antimicrobial Properties

Fernandes

Acharya

Bhatt

2018

Sci Rep

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“…In addition, hydrogen bonding would undergo dynamic destruction and reconstruction with the variation of temperature, pH, or solvent. 60,61 Plenty of hydrogen donors and acceptors in natural polysaccharides, such as −OH, −COOH, and −NH 2 , could create the conditions for the formation of hydrogen bonding, so most of natural macromolecules containing gelatin, collagen, agar, and starch can form hydrogel by hydrogen bonding. 62–64 Hydrogels cross-linked by hydrogen bonding alone are usually formed with some drawbacks, such as difficulty in injecting and weak mechanical strength due to their high content and low cross-link density.…”

Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Recent advances on polymeric hydrogels as wound dressings

Pan

2021

APL Bioengineering

108

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Severe hemorrhage is a leading cause of high mortality in critical situations like disaster, accidents, and warfare. The resulting wounds could induce severe physical and psychological trauma to patients and also bring an immense socio-economic burden. Hence, rapid hemostasis and wound healing techniques have become critical initiatives for life-saving treatment. Although traditional methods relying on bandages and gauzes are effective in controlling hemorrhage, they suffer from several limitations: nonbiodegradability, being susceptible to infection, being unsuitable for the irregular wound, secondary tissue damage, and being almost ineffective for wound healing. Owing to the merits of high porosity, good biocompatibility, tunable physicochemical properties, and being beneficial for wound healing, hydrogels with excellent performance have drawn intensive attention and numerous novel effective hydrogel dressings have been widely developed. In this Review, after introducing some commonly used strategies for the synthesis of hydrogels, the most recent progress on polymer-based hydrogels as wound dressings is discussed. Particularly, their hemostasis, antibacterial, and biodegradation properties are introduced. Finally, challenges and future perspectives about the development of hydrogels for wound dressings are outlined.

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“…Results showed the effective antimicrobial activity of the fabrics, which remained unchanged after 15 washing cycles. Bankoti et al [ 104 ] prepared hydrogels by blending WBPU and chitosan to obtain dried scaffolds, which were later crosslinked using a sodium tripolyphosphate solution. The WBPU/Cht blend becomes self-organized in a macroporous structure after the drying stage, facilitating protein adsorption and improving scaffolds’ stability in aqueous enzymatic environments, which make viable their use in biological media.…”

Section: Wbpu and Wbpuu Added With Renewable Additivesmentioning

confidence: 99%

Advances in Waterborne Polyurethane and Polyurethane-Urea Dispersions and Their Eco-friendly Derivatives: A Review

et al. 2021

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Polyurethanes and polyurethane-ureas, particularly their water-based dispersions, have gained relevance as an extremely versatile area based on environmentally friendly approaches. The evolution of their synthesis methods, and the nature of the reactants (or compounds involved in the process) towards increasingly sustainable pathways, has positioned these dispersions as a relevant and essential product for diverse application frameworks. Therefore, in this work, it is intended to show the progress in the field of polyurethane and polyurethane-urea dispersions over decades, since their initial synthesis approaches. Thus, the review covers from the basic concepts of polyurethane chemistry to the evolution of the dispersion’s preparation strategies. Moreover, an analysis of the recent trends of using renewable reactants and enhanced green strategies, including the current legislation, directed to limit the toxicity and potentiate the sustainability of dispersions, is described. The review also highlights the strengths of the dispersions added with diverse renewable additives, namely, cellulose, starch or chitosan, providing some noteworthy results. Similarly, dispersion’s potential to be processed by diverse methods is shown, evidencing, with different examples, their suitability in a variety of scenarios, outstanding their versatility even for high requirement applications.

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Accelerated healing of full thickness dermal wounds by macroporous waterborne polyurethane-chitosan hydrogel scaffolds

Cited by 78 publications

References 44 publications

Preparation of Lauroyl Grafted Alginate-Psyllium Husk Gel Composite Film with Enhanced Physicochemical, Mechanical and Antimicrobial Properties

Preparation of Lauroyl Grafted Alginate-Psyllium Husk Gel Composite Film with Enhanced Physicochemical, Mechanical and Antimicrobial Properties

Recent advances on polymeric hydrogels as wound dressings

Advances in Waterborne Polyurethane and Polyurethane-Urea Dispersions and Their Eco-friendly Derivatives: A Review

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