Accelerated Healing of Pyoderma Gangrenosum in Behçet Patient Treated With Cyclosporine and Split Thickness Skin Graft

Abstract

Pyoderma gangrenosum is a dermatologic manifestation of systemic disease such as inflammatory bowel disease, monoclonal gammopathy, arthritis, malignancies, and Behçet's disease. Pyoderma gangrenosum can be stabilized with oral cyclosporine administration. After stabilization, it can be managed with debridement and skin graft.

Clinical features of pyoderma gangrenosum and current diagnostic trends

“…Establishing firm criteria for diagnosing PG ensures that case reports describe the same disease, which has implications in optimizing treatment strategies and improving patient outcomes. 13 Ferrandiz-Pulido et al 13 Barker 14 Lindberg-Larsen and Fogh 15 Sripathi et al 16 Parren et al 17 27 Kim et al 28 Alkhouri et al 29 Tinoco et al 30 Spear 31 Mariscalco et al 32 Rashid 33 Aseni et al 34 …”

Genital ulcerative pyoderma gangrenosum in Behçet′s disease: A case report and review of the literature

“…Since, the first report by Munro and Cox in 1988[ 5 ] 13 cases of PG associated with BD have been reported in the literature[ 6 7 8 9 10 11 12 13 14 15 16 17 ] [ Table 1 ]. Both BD and PG belong to the category of the neutrophilic dermatoses, in which primary pustular lesions occur and neither of them has a characteristic histological appearance.…”

Pathergy phenomenon: an important clinical pointer to Behҫet disease

“…As the lesions were extensive and disfiguring, we planned to treat her with long-term immunosuppressive medication such as azathioprine or cyclosporine 2 3. On the basis of available literature for the management of PG-like lesions in BD and after discussion with the parents, she was started on oral cyclosporine (4 mg/kg/day) and oral prednisolone (2 mg/kg/day) that was later tapered and stopped in next 4 months.…”