Accelerated hyperfractionation radiation therapy after lumpectomy and axillary lymph node dissection in patients with stage I or II breast cancer: pilot study.

Abstract

This breast-conservation accelerated hyperfractionation radiation therapy schedule is tolerable. Additional follow-up is necessary to determine long-term morbidity and cosmesis, and further study in a larger patient group is necessary to confirm efficacy.

Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients

“…There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively, p = 0.30) or in grades 1-2 toxicity (20.8% vs. 25.5% respectively, p = 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups (p = 0.80) Current OnCOlOgy-VOlume 17, number 5 controlled trials in which hypofractionation was shown to achieve local control similar to that with standard fractionation [6][7][8][9] , without an increase in long-term side effects, this approach was adopted in several parts of the world, including Canada and the United Kingdom.…”

“…Although this treatment scheme has been widely adopted, much debate remains about the ideal radiotherapy regimen to use. Several alternative fractionation regimens have recently been assessed 5 and compared with the standard fractionation schedule (25 fractions of 2 Gy each over 5 weeks) [6][7][8][9] .…”

Growth Laws in Cancer: Implications for Radiotherapy

“…The previous interesting clinical results are further investigated by considering the UL and the GL with different treatment schedules. In particular,since clinical experience confirms that highly proliferative tumors are unsatisfactorily treated by conventional RT schedule, we have performed simulations by assuming non-conventional, yet widely applied RT schedules, such as hyperfractionation [20], CHART protocol [21] and hypofractioned regimes [22], which are known to be more effective in controlling the evolution of highly proliferative tumors.…”

“…Actually, clinical experience confirms that highly proliferative tumors are unsatisfactorily treated by conventional RT schedule. Simulations are therefore proposed by assuming non-conventional RT schedules such as accelerated hyperfractionation [20], CHART protocol [21] and hypofractioned regimes [22].…”

“…Simulations are therefore proposed by assuming non-conventional RT schedules such as accelerated hyperfractionation [20], CHART protocol [21] and hypofractioned regimes [22].…”