Accelerated long-term forgetting: A newly identified memory impairment in epilepsy

Fitzgerald, Zoë; Mohamed, Armin; Ricci, Monica; Thayer, Zoë; Miller, Laurie A.

doi:10.1016/j.jocn.2013.04.037

Cited by 42 publications

(42 citation statements)

References 58 publications

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“…The authors reported the occurrence of ALF over a period of 12 hours of wakefulness, but not over a comparable period of sleep, suggesting that ALF is not caused by disruption of sleepdependent memory consolidation. These results are in line with other findings in temporal lobe epilepsy [38,49,50]. However, some patients exhibit ALF over hours [26,27], while others over days, weeks or months [9,16,22,28].…”

Section: Accelerated Rate Of Forgettingsupporting

confidence: 92%

“…Several mechanisms have been posited, including the cognitive effects of antiepileptic drugs (AED), clinical and subclinical epileptic activity, and disrupted sleep (for review, see [36][37][38]). However, the adverse effects of AEDs are the unlikely culprits of ALF, as this phenomenon typically pre-dates the onset of treatment [7,14,16,39].…”

Section: Accelerated Rate Of Forgettingmentioning

confidence: 99%

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Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

2015

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Section: Accelerated Rate Of Forgettingsupporting

confidence: 92%

Section: Accelerated Rate Of Forgettingmentioning

confidence: 99%

Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

2015

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“…The observed change in retrieval of contextual detail between our thalamic patients and controls in the first week, despite reaching the same level of encoding, behaviorally resembles the accelerated long-term forgetting (ALF) phenomenon identified in some patients with temporal lobe epilepsy (for a review see, Fitzgerald et al, 2013). Notably, some patients show rapid forgetting from as early as 24 h despite normal learning and initial retention, and intact hippocampus (Mayes et al, 2003; Muhlert et al, 2010).…”

Section: Discussionsupporting

confidence: 70%

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Miller

Piguet

et al. 2014

Front. Behav. Neurosci.

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Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.

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“…Some have described a pattern of memory decay known as 'accelerated long-term forgetting', thought to be related to deficits in memory consolidation Butler & Zeman, 2008b;Fitzgerald, Mohamed, Ricci, Thayer, & Miller, 2013;Hoefeijzers, Dewar, Della Sala, Zeman, & Butler, 2013). This notion refers to findings that people with TLE can appear to perform 'normally' on standard neuropsychological anterograde memory tests (where recall is typically assessed within 30 to 45-minutes following new learning) yet show evidence of faster forgetting at later, 'long-term', delay intervals.…”

Section: Introductionmentioning

confidence: 99%

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Cassel

Morris

Koutroumanidis

et al. 2016

Cortex

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The notion of 'accelerated long-term forgetting' has often been attributed to disrupted 'late' memory consolidation. Nevertheless, methodological issues in the literature have left this theory unproven, leading some to suggest such findings may be reflective of subtle acquisition or early retention deficits. This study attempts to address such issues, and also to explore which pathophysiological variables are associated with forgetting rates. Eighteen participants with temporal lobe epilepsy (TLE) and eighteen matched controls completed background neuropsychological measurement of immediate and short-delay memory that showed comparable performance, both on verbal and visual tests. Using two novel experimental tasks to measure long-term forgetting, cued recall of verbal and visuospatial material was tested 30 seconds, 10 minutes, one day, and one week after learning. Forgetting of verbal material was found to be progressively faster during the course of a week in the TLE group. For visuospatial memory, participants in the TLE group exhibited faster early forgetting in the first 10 minutes after learning, as indicated by planned comparisons, with comparable forgetting rates thereafter. Our findings provide evidence for two patterns of disruption to 'early' memory consolidation in this population, occurring either at the initial delay only or continuing progressively through time. Differences in how soon after learning accelerated forgetting was detectable were related to factors associated with greater severity of epilepsy, such as presence of medial temporal lobe sclerosis on MRI and use of multiple anti-epileptic agents.

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Accelerated long-term forgetting: A newly identified memory impairment in epilepsy

Cited by 42 publications

References 58 publications

Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Forgetting in temporal lobe epilepsy: When does it become accelerated?

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