Accelerated long-term forgetting in neurodegenerative disorders: A systematic review of the literature

Rodini, Marta; Simone, Maria Stefania De; Caltagirone, Carlo; Carlesimo, Giovanni Augusto

doi:10.1016/j.neubiorev.2022.104815

Cited by 14 publications

(6 citation statements)

References 85 publications

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“…Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is commonly known as senile dementia and is characterized by cognitive decline and memory loss [1,2]. It is the most prevalent form of dementia in the aging population [3], leading to irreversible damage in various brain regions [4].…”

Section: Introductionmentioning

confidence: 99%

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Farihi,

Bouhrim,

Chigr

et al. 2023

Medicina

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Background and Objectives: Alzheimer’s disease (AD) stands as a pervasive neurodegenerative ailment of global concern, necessitating a relentless pursuit of remedies. This study aims to furnish a comprehensive exposition, delving into the intricate mechanistic actions of medicinal herbs and phytochemicals. Furthermore, we assess the potential of these compounds in inhibiting human acetylcholinesterase through molecular docking, presenting encouraging avenues for AD therapeutics. Materials and Methods: Our approach entailed a systematic exploration of phytochemicals like curcumin, gedunin, quercetin, resveratrol, nobiletin, fisetin, and berberine, targeting their capability as human acetylcholinesterase (AChE) inhibitors, leveraging the PubChem database. Diverse bioinformatics techniques were harnessed to scrutinize molecular docking, ADMET (absorption, distribution, metabolism, excretion, and toxicity), and adherence to Lipinski’s rule of five. Results: Results notably underscored the substantial binding affinities of all ligands with specific amino acid residues within AChE. Remarkably, gedunin exhibited a superior binding affinity (−8.7 kcal/mol) compared to the reference standard. Conclusions: These outcomes accentuate the potential of these seven compounds as viable candidates for oral medication in AD treatment. Notably, both resveratrol and berberine demonstrated the capacity to traverse the blood-brain barrier (BBB), signaling their aptitude for central nervous system targeting. Consequently, these seven molecules are considered orally druggable, potentially surpassing the efficacy of the conventional drug, donepezil, in managing neurodegenerative disorders.

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Section: Introductionmentioning

confidence: 99%

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Farihi,

Bouhrim,

Chigr

et al. 2023

Medicina

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“…After grouping PWE based on ictal events rather than the type of epilepsy, accelerated forgetting was observed between delays of 30 min and 4 weeks both in those patients who presented with seizures and those without. This further suggests that ictal events may not be essential for an increase in the rate of forgetting among PWE, especially considering the growing body of evidence that ALF is not epilepsy‐specific 5,6,19 . On the other hand, it may be noted that lesional causes of epilepsy (however, rarely including hippocampal sclerosis) were present in most individuals with ALF.…”

Section: Discussionmentioning

confidence: 99%

“…This further suggests that ictal events may not be essential for an increase in the rate of forgetting among PWE, especially considering the growing body of evidence that ALF is not epilepsy-specific. 5,6,19 On the other hand, it may be noted that lesional causes of epilepsy (however, rarely including hippocampal sclerosis) were present in most individuals with ALF. Given the limited number of TLE cases in the current study, we could not provide robust evidence of this association, but our data is in line with previous findings, suggesting that the etiology of epilepsy differentially affects ALF and that ALF is rare in patients with hippocampal sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Longer‐term verbal and visual memory patterns in patients with temporal lobe and genetic generalized epilepsies

2023

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ObjectiveTo compare forgetting patterns between patients with temporal lobe (TLE) and generalized (GGE) epilepsies and to assess whether recall is associated with epileptic activity.MethodsThirty‐three patients with TLE (13 left, 17 right, and 3 nonlateralized TLE), 42 patients with GGE, and 57 healthy controls (HCs) were asked to recall words, verbal story material, and the Rey‐Osterrieth complex figure at two delays. Accelerated long‐term forgetting (ALF) was defined by group performance comparable to HCs at 30 min and worse recall than HCs after 4 weeks. ALF was assessed by comparing raw test scores in a two‐way repeated measures analysis of variance (ANOVA) adjusted for the learning capacity.ResultsCompared to HCs, patients with R‐TLE remembered fewer items of the word list after 30 min as well as after 4 weeks. Patients with L‐TLE and GGE had comparable learning‐adjusted performance to HCs at the 30 min delay but scored less after 4 weeks (group by delay interaction F(3, 124) = 3.2, P = 0.026, = 0.07). The epilepsy group (patients with TLE and GGE combined) performed as well as HCs at 30 min but worse after 4 weeks irrespective of experienced seizures during the 4‐week delay or interictal bilateral (TLE) or generalized (GGE) activity before the study. We noted no statistically significant differences between patient and HC verbal story (group by delay interaction F(3, 124) = 0.7, P = 0.570, = 0.02) or complex figure (F(3, 124) = 0.8, P = 0.488, = 0.02) recall.SignificanceOur data support verbal and visual memory impairment in both TLE and GGE with different performances between these groups in the task of word recall. We suggest the presence of ALF in patients with GGE and left TLE after adjusting for learning capacity. We could not confirm the influence of epileptic activity on long‐term forgetting patterns. Future studies are required to better define domain‐specific differences in memory impairment in TLE and GGE.

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“…The memory deficits seen in TLE are believed to result from difficulty consolidating newly learned information. On testing, this is displayed as rapid forgetting ( 58 ). These could be secondary to early involvement of dentate gyrus/CA3 and CA1, subfields responsible for pattern separation and integration ( Figures 3 , 4 ; Table 1 ) ( 29 , 35 ).…”

Section: Characterizing Ad and Loe Cognitive Phenotypesmentioning

confidence: 99%

Overlapping and distinct phenotypic profiles in Alzheimer’s disease and late onset epilepsy: a biologically-based approach

Liu,

Barr

2024

Front. Neurol.

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Due to shared hippocampal dysfunction, patients with Alzheimer’s dementia and late-onset epilepsy (LOE) report memory decline. Multiple studies have described the epidemiological, pathological, neurophysiological, and behavioral overlap between Alzheimer’s Disease and LOE, implying a bi-directional relationship. We describe the neurobiological decline occurring at different spatial in AD and LOE patients, which may explain why their phenotypes overlap and differ. We provide suggestions for clinical recognition of dual presentation and novel approaches for behavioral testing that reflect an “inside-out,” or biologically-based approach to testing memory. New memory and language assessments could detect—and treat—memory impairment in AD and LOE at an earlier, actionable stage.

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Accelerated long-term forgetting in neurodegenerative disorders: A systematic review of the literature

Cited by 14 publications

References 85 publications

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Longer‐term verbal and visual memory patterns in patients with temporal lobe and genetic generalized epilepsies

Overlapping and distinct phenotypic profiles in Alzheimer’s disease and late onset epilepsy: a biologically-based approach

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