Abstract:Human induced pluripotent stem cell‐derived (iPSC) neurons are increasingly being used as a platform for neurological disease modeling, high throughput/content screening and drug discovery. However, the differentiation and maturation of iPSC‐derived neurons is not standardized and varies in methodology (i.e., timing) limiting their usefulness in automated drug screening platforms. To generate mature iPS‐derived neurons for high content screening, we derived neuronal progenitor cells (NPCs) from the normal iPSC… Show more
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