Accelerated Myelinogenesis by Dietary Lipids in Rat Brain

Salvati, Serafina; Sanchez, Massimo; Campeggi, Lorenzo Malvezzi; Suchanek, Gerda; Breitschop, Helene; Lassmann, Hans

doi:10.1046/j.1471-4159.1996.67041744.x

Cited by 32 publications

(35 citation statements)

References 22 publications

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“…From studies in rat, it became clear that the brain is clearly sensitive to alteration of dietary lipid intake (Foot et al, 1982). Moreover, myelin formation in the rat brain can be accelerated by dietary lipids (Salvati et al, 1996). Postnatal deficiency of essential fatty acids reduces the mRNA levels of specific oligodendrocyte myelin proteins in the mouse brain (DeWille & Farmer, 1992).…”

Section: Cns Bioavailability Of Dietary Antioxidants and Pufasmentioning

confidence: 99%

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Meeteren¹,

Teunissen

Dijkstra

et al. 2005

Eur J Clin Nutr

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Section: Cns Bioavailability Of Dietary Antioxidants and Pufasmentioning

confidence: 99%

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Meeteren¹,

Teunissen

Dijkstra

et al. 2005

Eur J Clin Nutr

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“…The amount of probe hybridised to the blot was quantitated on a 2202 Ultrascan laser densitometry. The arrowhead indicates 2.4-kb mRNA PLP [38].…”

Section: Dietary Fatty Acids and Myelinmentioning

confidence: 99%

“…By contrast, in tests, the MOG transcript was detected both in the medulla and cerebellum, suggesting an accelerated gradient of developmental expression in these animals ( fig. 3) [38]. Although it is still not known if an increase in myelin protein mRNAs is due to either an up-regulation of gene expression or mRNA stabilisation mechanism, surely this increase is reflected in an increased number of differentiated oligodendrocytes [38].…”

Section: Dietary Fatty Acids and Myelinmentioning

confidence: 99%

“…3) [38]. Although it is still not known if an increase in myelin protein mRNAs is due to either an up-regulation of gene expression or mRNA stabilisation mechanism, surely this increase is reflected in an increased number of differentiated oligodendrocytes [38]. In fact in situ hybridisation studies have shown an increased number of positively stained oligodendrocytes for both PLP, MBP and MOG mRNAs in all brain regions of rats fed the test diet compared with animals fed the control diet.…”

Section: Dietary Fatty Acids and Myelinmentioning

confidence: 99%

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Diet, Lipids and Brain Development

Salvati¹,

Attorri²,

Avellino³

et al. 2000

Dev Neurosci

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Brain development is a sequential anatomical process characterised by specific well-defined stages of growth and maturation. One of the fundamental and necessary events in the normal development of the central nervous system in vertebrates is the formation of a myelin sheath. It is becoming more evident that this process is influenced by dietary lipids. A number of findings have indicated that the administration of a diet deficient in essential fatty acids during development causes hypomyelination in the rat brain. Our studies have shown that lipids can also play a role in accelerating myelinogenesis in the brain of rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n-alkanes. Further studies have shown that accelerated myelinogenesis is connected to a precocious appearance of behavioural reflexes. Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development.

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“…Moreover, studies in rats have clearly shown the brain to be sensitive to alterations in dietary lipid intake, even with a nutritionally complete diet [25] . Myelin formation in the rat brain can be accelerated by dietary lipids [26] , and postnatal defi ciency in essential fatty acids reduces oligodendrocyte myelin basic protein (MBP) and proteolipid protein (PLP) mRNA levels in the mouse brain [27] . Furthermore, oral feeding of ␥ -linolenic acid (GLA; 18: 2n-6) ameliorates the course of both acute and chronic experimental autoimmune encephalomyelitis [28] .…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid Supplementation Stimulates Differentiation of Oligodendroglia Cells

Meeteren¹,

Baron

Beermann

et al. 2006

Dev Neurosci

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Dietary polyunsaturated fatty acids (PUFAs) have been postulated as alternative supportive treatment for multiple sclerosis, since they may promote myelin repair. We set out to study the effect of supplementation with n-3 and n-6 PUFAs on OLN-93 oligodendroglia and rat primary oligodendrocyte differentiation in vitro. It appeared that OLN-93 cells actively incorporate and metabolise the supplemented PUFAs in their cell membrane. The effect of PUFAs on OLN-93 differentiation was further assessed by morphological and Western blot evaluation of markers of oligodendroglia differentiation: 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP), zonula occludens-1 (ZO-1) and myelin-associated glycoprotein (MAG). Supplementation of the OLN-93 cells with n-3 and n-6 PUFAs increased the degree of differentiation determined by morphological analysis. Moreover, CNP protein expression was significantly increased by γ-linolenic acid (GLA, 18:3n-6) supplementation. In accordance with the OLN-93 results, studies with rat primary oligodendrocytes, a more advanced model of cell differentiation, showed GLA supplementation to promote oligodendrocyte differentiation. Following GLA supplementation, increased numbers of proteolipid protein (PLP)-positive oligodendrocytes and increased myelin sheet formation was observed during differentiation of primary oligodendrocytes. Moreover, increased CNP, and enhanced PLP and myelin basic protein expression were found after GLA administration. These studies provide support for the dietary supplementation of specific PUFAs to support oligodendrocyte differentiation and function.

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Accelerated Myelinogenesis by Dietary Lipids in Rat Brain

Cited by 32 publications

References 22 publications

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Diet, Lipids and Brain Development

Polyunsaturated Fatty Acid Supplementation Stimulates Differentiation of Oligodendroglia Cells

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