2010
DOI: 10.1186/1748-717x-5-56
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Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

Abstract: BackgroundTo investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.MethodsBetween 2002 and 2006, 48 prospectively selected patients with early-stage breast cancer received APBI using multicatheter brachytherapy following breast-conserving surgery. Their median age was 52 years (range 36-78). A median of 34 Gy (range 30-34) in 10 fractions given twice daily within 5 days was delivered t… Show more

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Cited by 33 publications
(21 citation statements)
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“…We compared our study with a recent study conducted by Yeo et al [11]. The previous study included 10 patients with replacement of over three-quarters of normal liver by metastatic tumors and Child-Pugh classification B or C. The serum levels of AST, ALP, and TB were higher in the previous study (median of 118 IU/L, 583 IU/L, and 6.5 mg/dL, respectively) than in our study (median of 94 IU/L, 364 IU/L, and 2.6 mg/dL, respectively).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We compared our study with a recent study conducted by Yeo et al [11]. The previous study included 10 patients with replacement of over three-quarters of normal liver by metastatic tumors and Child-Pugh classification B or C. The serum levels of AST, ALP, and TB were higher in the previous study (median of 118 IU/L, 583 IU/L, and 6.5 mg/dL, respectively) than in our study (median of 94 IU/L, 364 IU/L, and 2.6 mg/dL, respectively).…”
Section: Discussionmentioning
confidence: 99%
“…The median dose was 21 Gy in 7 fractions. Four of 10 patients who had improvement in liver function after WLRT received further chemotherapy and showed better survival, with a mean survival time of 143 days [11]. …”
Section: Introductionmentioning
confidence: 99%
“…However, compared with studies in European countries and the United States, few studies have evaluated this technique in Asian patients with breast cancer (Mitsumori, & Hiraoka, 2008;Yeo et al, 2010). To our knowledge, this is one of the largest prospective observational studies from Asia, demonstrating the feasibility of BCT using multicatheter brachytherapy and showing acceptable clinical outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…[3] Late toxicity of the skin and subcutaneous tissue was scored according to the Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer late radiation morbidity scoring scheme. [4,6] …”
Section: Methodsmentioning
confidence: 99%
“…Besides BT has the added advantage of partial breast irradiation (PBI) sparing lots of normal tissue from unnecessary irradiation with shortened duration of treatment. [4][5][6] With this background, our experience in the long term follow-up are discussed. In BCT besides organ preservation, cosmesis is considered an important factor.…”
Section: Introductionmentioning
confidence: 99%