Accelerated photostability study of tretinoin and isotretinoin in liposome formulations

Ioele, Giuseppina; Cione, Erika; Risoli, Antonella; Genchi, Giuseppe; Ragno, Gaetano

doi:10.1016/j.ijpharm.2005.01.012

Cited by 95 publications

(68 citation statements)

References 31 publications

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“…3). This observation is in contrast to earlier studies (Brisaert and Plaizier-Vercammen 2000;Manconi et al 2003;Ioele et al 2005), most likely to due to the different conditions present in relatively dermatological preparations.…”

Section: Determination Of Kinetic Parameters Of Photodegradationcontrasting

confidence: 99%

“…Orfanos et al 1997;Chivot 2005;Kang et al 2005). Retinoids have been shown to undergo degradation when exposed to light generating RA isomers of which 13RA and 9RA are the most prevalent (Curley and Fowble 1988;Lucero et al 1994;Brisaert et al 1995;Cahnmann 1995;Brisaert and Plaizier-Vercammen 2000;Ioele et al 2005). Light exposure also leads to degradation to non-retinoid products (Curley and Fowble 1988).…”

Section: Introductionmentioning

confidence: 99%

“…The chemical stability of RA in ethanol and niosomes under UV and artificial light conditions has been studied and incorporation of RA in niosomes led to reduce the rates of the photodegradation (Manconi et al 2003). The photodegradation process of RA and 13RA in ethanol and liposomes has been studied by UV spectrophotometry and RA was found to rapidly isomerizes in ethanol to 13 RA and 9RA with first-order kinetics (Ioele et al 2005). Other studies also have reported RA degradation to follow first-order kinetics (Brisaert and Plaizier-Vercammen 2000;Ioele et al 2005) while studies reporting degradation to follow zero-order kinetics have appeared (Manconi et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Tashtoush

Jacobson

2008

International Journal of Pharmaceutics

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The chemical stability of tretinoin (RA) and isotretinoin (13RA) in ethanol and dermatological cream preparations exposed to solar simulated light (SSL), UVA, and visible light has been studied. Photostability was monitored by an HPLC method that allowed simultaneous analysis of RA and 13RA, thus allowing photodegradation due to isomerization to other retinoids and photolysis to nonretinoid products to be monitored. Both retinoids undergo both isomerization and photolysis following SSL, UVA and visible light exposure but RA is more sensitive to photodegradation than 13RA. Degradation of both retinoids by photolysis is considerably greater in cream formulations than in ethanol and the photodegradation follows second order kinetics. Rate constants and half-lives for degradation of RA and 13RA in ethanol solution and cream preparations subjected to different light sources are reported. The UVA component of SSL is the major contributor to photodegradation. Since UVA penetrates deeply into skin, our results suggest that photodegradation of RA may contribute to the photosensitivity associated with RA therapy. Our studies suggest that development of improved formulations and the use of effective UVA sunscreens may reduce the side effects of RA therapy.

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Section: Determination Of Kinetic Parameters Of Photodegradationcontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Tashtoush

Jacobson

2008

International Journal of Pharmaceutics

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“…Photodegradation of IT was monitored by recording its absorption spectra at the wavelength of 349 nm. A placebo dispersion was diluted suitably with methanol to omit any possible absorption arising from the solid lipid (19,20).…”

Section: Entrapment Efficiency (Ee) -mentioning

confidence: 99%

“…Strips 1-2, 3-7, 8-12, 13-17, 18-22 were pooled separately in different groups. These strips were named group 1 (strips 1-2), group 2 (strips 3-7), group 3 (strips 8-12), group 4 (strips 13-17) and group 5 (strips [18][19][20][21][22], indicating the different layers of stratum corneum. Methanol (1 mL) was added to the strips, and each sample was shaken 10 s with a vortex, followed by centrifugal separation.…”

Section: Entrapment Efficiency (Ee) -mentioning

confidence: 99%

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Golmohammadzadeh¹,

Somaye²,

Reza³

2012

Acta Pharmaceutica

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Isotretinoin (IT) is used orally for the treatment of severe acne that has not responded to other measures. IT has also been tried in a number of other skin disorders and in some forms of neoplastic disease. It has obvious adverse side effects in oral administration. The most common is dryness of the mucous membranes, visual disturbances, skeletal hyperostosis, and musculoskeletal symptoms. Elevation of serum triglycerides, blood glucose and hepatic enzymes has also been reported (1, 2). However, topical preparations of IT are available, such as creams and gels that show systemic absorption. The topical utility of IT is strongly limited by several disadvantages, such as skin irritation, very low water solubility, and high instability in the presence of light, air and heat. The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure homogenization method. Size, zeta potential and morphological characteristics of the preparations were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC). IT-SLNs had a small average diameter of 74.05 ± 8.91 nm and high encapsulation efficiency (EE) of 80.6 ± 1.2 %. The results showed that the entrapment of IT into SLNs reduced significantly its photodegradation. The in vitro permeation data showed that IT-SLNs can accumulate in the different layers of the skin and prevent systemic uptake of IT in mouse skin. IT-SLNs also significantly increased IT accumulation in the different layers of the stratum corneum of human skin. IT-SLN formulation was significantly less irritating compared to commercial IT-GEL, which shows its potential for improving skin tolerability and being a carrier for topical delivery of IT.

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Development of Smart Semisolid Formulations to Enhance Retinoic Acid Topical Application

Perioli

Pagano

Nocchetti

et al. 2015

Journal of Pharmaceutical Sciences

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Accelerated photostability study of tretinoin and isotretinoin in liposome formulations

Cited by 95 publications

References 31 publications

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Development of Smart Semisolid Formulations to Enhance Retinoic Acid Topical Application

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