Accelerated radiation retinopathy in diabetes and pregnancy

“…A recent retrospective review suggests that this incidence can be significantly reduced by hyperfractionated (twice daily doses of 1.1-1.2 Gy) EBRT, especially when the retina receives more than 50 Gy (Monroe et al 2005). The effect of radiation is, however, augmented by comorbidities such as diabetic retinopathy, hypertension, simultaneous chemotherapy and by pregnancy Viebahn et al 1991;Kumar & Palimar 2000).…”

Section: Retinamentioning

confidence: 99%

Ophthalmic and adnexal complications of radiotherapy

Durkin

Roos

Higgs

et al. 2006

Acta Ophthalmologica Scandinavica

136

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ABSTRACT.The role of radiotherapy in ophthalmic practice continues to grow. This growth has seen an expansion of indications for radiotherapy, a refinement of the modalities that can be used and a reduction in the ocular and adnexal complications that result from this form of therapy. The compendium of indications for radiotherapy in ophthalmology continues to grow and now includes many conditions such as the treatment of lid and adnexal disease, ocular surface disorders and both benign and malignant disease of the posterior segment and optic pathways. The radiotherapeutic modalities employed to manage these conditions are numerous and include both radioactive plaques (brachytherapy) and external beam radiation techniques. New techniques such as stereotactic radiosurgery are delivering benefits in the management of conditions such as optic nerve sheath meningioma, where the treatment of this blinding and occasionally life-threatening intracranial neoplasm now results in fewer adverse affects. The purpose of this review is to give a brief overview of the indications and treatment modalities, and a more in-depth discussion of the potential side-effects when radiotherapy is used for ocular and periorbital disease.

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“…The TD 5/5 of the retina is estimated to be 45 to 50 Gy, and the TD 50/5 is 55 Gy (22). The risk of radiation retinopathy is increased by coexistent diabetic retinopathy (46), hypertension, collagen vascular disease, simultaneous chemotherapy, and pregnancy (46), where the latent period for developing injury is shorter and the risk of developing blindness higher.…”

Section: Late Toxicitymentioning

confidence: 99%