Accelerated solvent extraction of phenolic compounds exploiting a Box-Behnken design and quantification of five flavonoids by HPLC-DAD in Passiflora species

Gomes, Silvana Vieira Floresta; Portugal, Lindomar A.; Anjos, Jeancarlo Pereira dos; Jesus, O. N. de; Oliveira, E. J. de; David, Juceni P.; David, Jorge

doi:10.1016/j.microc.2016.12.021

Cited by 109 publications

(74 citation statements)

References 25 publications

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“…Furthermore, the best recoveries for naringenin isomer 1 and chrysin were achieved by PLE using 85% ethanol as solvent at 176°C. These results were consistent with that reported by Gomes et al indicating a high extraction efficiency of flavonoids from Passiflora species leaves when ethanol was used in higher percentage. Concerning some flavonoids and all flavonoid derivatives, SFE using 7% of co‐solvent proved to have a poor recovery for these compounds.…”

Section: Resultssupporting

confidence: 93%

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

Nastić

Lozano-Sánchez²,

Borrás-Linares³

et al. 2019

Phytochemical Analysis

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Introduction In recent years, an increasing interest in biological properties of sweet cherry (Prunus avium L.) stems has resulted in increased attention for advanced extraction techniques and their optimisation. Objectives In the present study chemical profiles of P. avium stems extracts obtained by selected emerging technologies, such as pressurised liquid extraction (PLE) and supercritical fluid extraction (SFE), under different experimental conditions were compared. Material and Methods All SFEs were carried out at 40°C in a dynamic mode with different solvent combinations (CO2 plus ethanol at 7 and 15%) and pressures (150 and 300 bar). The PLE experiments were performed in a static mode for all tested combinations of extraction solvent (ethanol–water from 0% to 100%) at temperatures ranging from 40 to 200°C. A complete analytical characterisation of cherry stem extracts was performed by high‐performance liquid chromatography coupled to electrospray ionisation quadrupole time‐of‐flight mass spectrometry (HPLC‐ESI‐QTOF‐MS). Results PLE showed to be more efficient than SFE removing a wide variety of compounds with different polarities being phenols the most abundant, whereas SFE resulted in a higher amount of fatty acids and derivatives. Chemical characterisation of the extracts was carried out by HPLC‐ESI‐QTOF‐MS yielding in total 42 identified compounds, among which 22 compounds were identified in P. avium stems for the first time. Conclusion These results point out the possibility of sweet cherry stem extracts to be incorporated in formulations manufactured by food and pharmaceutical industry. Also, these new thermal and high‐pressure industrial technologies proved to be promising candidates in the valorisation of sweet cherry by‐product.

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Section: Resultssupporting

confidence: 93%

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

Nastić

Lozano-Sánchez²,

Borrás-Linares³

et al. 2019

Phytochemical Analysis

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“…Moreover, as a favorable type of design for supporting a response surface, BBD is further employed to assess second-order multivariate technique in terms of three-level synsemantic factorial design [31]. BBD has been generally performed to optimize the extraction process of bioactive components from natural raw materials since it offers sufficient information about the main and interaction effects, which cannot be easily evaluated by univariate techniques [32,33]. Additionally, the model outcomes can be clearly exhibited on the response surface plot.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Deng

Liu

Zou

2019

Journal of Chemistry

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A microwave-assisted extraction (MAE) method was applied to separate saponins from Sapindus mukorossi pericarps. The most important factors of the six extraction parameters were selected using Plackett–Burman designs; therefore, the further extraction procedure was optimized using the Box–Behnken designs; meanwhile, the optimum processing parameters and well-pleasing saponins extraction rate were inferred. The final operation conditions were the ethanol concentration of 40%, soaking time of 3 h, particle size of 80–100 meshes, extraction time of 13 min, solvent-solid ratio of 19 mL/g, and microwave power of 425 W. Based on the optimal extraction parameters, the extraction rate of the saponins by means of MAE technique reached 280.55 ± 6.81 mg/g, which exceeds yields acquired using conventional manners. Saponins from S. mukorossi have obvious xanthine oxidase inhibitory properties in vitro compared with allopurinol. The saponins displayed a type of competitive inhibition of xanthine oxidase. In conclusion, a MAE technique in association with a response surface design provides an efficient extraction tactics, which could sufficiently isolate saponins from S. mukorossi pericarps; further, this technique could be applied to the dissociation of other bioactive substances from plant sources. In addition, the saponins may be a promising alternative to conventional medicine to treat gout and other inflammation-associated disorders to mitigate the side effects of traditional drugs.

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“…The extractive process used for the ELPA was ASE, developed to maximize the yield of the extract and simultaneously the content of flavonoids (18). According Pearson et al (2010) (32) and Saha et al (2015) (33), the process is promising, because it offers advantages over other extraction processes such as: easy automation, faster sample analysis, better reproducibility, less solvent required, and sample maintenance in an environment without light and free of oxygen.…”

Section: Resultsmentioning

confidence: 99%

“…The plant material was extracted under optimized conditions in five extraction cycles with 64% (w/w) ethanol at 80°C, 1500 psi, and a static cycle timing of 10 min. The cells were then rinsed with fresh extraction solvent (100% of the extraction cell volume) and purged with N 2 gas for 60 s. The solvent was removed under reduced pressure at 55°C to yield the corresponding crude extracts, which were stored under refrigeration and protected from light (18).…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of the cytotoxic potential of extracts from the genus Passiflora cultived in Brazil against cancer cells

Svf

Âr

et al. 2018

Preprint

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Abstract20 This work aimed to evaluate the cytotoxic potential against cancer cells of Passiflora genus 21 plant species cultivated in Brazil and identify the mechanism of cytotoxicity induced by the 22 most promising extract. Leaf extracts from 14 Passiflora (P.) species were obtained ASE and 23 in vitro cytotoxicity evaluated against cancer cell lines using MTT assay at a single . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

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Accelerated solvent extraction of phenolic compounds exploiting a Box-Behnken design and quantification of five flavonoids by HPLC-DAD in Passiflora species

Cited by 109 publications

References 25 publications

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Evaluation of the cytotoxic potential of extracts from the genus Passiflora cultived in Brazil against cancer cells

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