“…When this balance is disturbed, chronic and/or overzealous activation of immune pathways through autoimmunity results in unremitting inflammation, as observed in common skin diseases, including psoriasis (T H 17 centered), cutaneous lupus (T H 1 and interferon centered), 33 and atopic dermatitis (AD; T H 2 centered). 17,[34][35][36][37][38][39][40][41] The latter illustrates the importance and therapeutic potential of the skin as an immune organ: in AD, eosinophils are recruited into the skin by chemokines, including IL-5, and increased T H 2 activation drives production of IL-4 and IL-13, promoting IgE production. This in turn contributes to increased risk of IgE-mediated allergic reactions, food sensitivities, asthma, or autoimmunity.…”