Accelerated versus conventional corneal collagen cross-linking in patients with keratoconus: an intrapatient comparative study

Sadoughi, Mohammad Mehdi; Einollahi, Bahram; Baradaran‐Rafii, Alireza; Roshandel, Danial; Hasani, Hamidreza; Mehrdad, Neda

doi:10.1007/s10792-016-0423-0

Cited by 49 publications

(56 citation statements)

References 33 publications

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“…Sadoughi et al. () showed no significant correlation between changes in ECD and CCT in any of the groups. Thus, it is supposed that in practice, endothelial cell loss does not depend on whether the cornea is rather thin or thick.…”

Section: Discussionmentioning

confidence: 91%

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Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Shajari

Kolb

Agha

et al. 2018

Acta Ophthalmologica

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Section: Discussionmentioning

confidence: 91%

“…; Sadoughi et al. ) postoperatively. Although C‐CXL showed a smaller reduction in CH and CRF, statistical significance was missed comparing changes among both groups (p = 0.21 and 0.46 respectively) (Fig.…”

Section: Resultsmentioning

confidence: 98%

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Shajari

Kolb

Agha

et al. 2018

Acta Ophthalmologica

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“…Table 3 is a summary of previous studies on the longterm changes in the central ECD (spanning more than 2 years), and those on the changes in the central CV and HEX after CXL. Several studies on corneal endothelial cell after CXL have been published, however all studies focused on the endothelial cell density and the morphology only in the central cornea in post-CXL eyes [10][11][12][13][14][15][16][17][18][19][20][21]. The mean central ECD loss was − 0.1 to 7.5%, which was largely different among previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of corneal cross-linking on endothelial cell density and morphology in the peripheral cornea

et al. 2020

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Background: To compare the endothelial cell density and morphology in the peripheral cornea before and after corneal cross-linking (CXL). Methods: This study evaluated thirty-one eyes of 31 patients who were treated with standard CXL for progressive keratoconus. Preoperatively and 6 months postoperatively, we compared the corneal endothelial cell density (ECD), the coefficient of variation in cell size (CV), and the percentage of hexagonal cells (HEX), in the peripheral regions of the cornea, using a non-contact specular microscope (EM-3000, Tomey). Results: All keratoconic eyes in this series were measurable in the peripheral regions. No significant differences were found in the peripheral ECD preoperatively and 6 months postoperatively at each point (Wilcoxon signed-rank test, superior, p = 0.16, nasal superior, p = 0.12, temporal superior, p = 0.17, inferior, p = 0.37, nasal inferior, p = 0.28, temporal inferior, p = 0.17). The mean percentage of the ECD loss was 1.3, 1.3, 1.0, 1.4, 0.7, and 1.4%, respectively. No significant differences in the peripheral CV or HEX were found preoperatively and 6 months postoperatively at each point. Conclusions: Standard CXL does not cause significant changes in endothelial cell density, polymegethism, or polymorphism, in the peripheral regions of the cornea. It is suggested that CXL is a minimally invasive surgical approach for progressive keratoconus, even in terms of peripheral endothelial cells.

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“…Several studies on corneal endothelial cell after CXL have been published, however all studies focused on the endothelial cell density and the morphology only in the central cornea in post-CXL eyes. [10][11][12][13][14][15][16][17][18][19][20][21] The mean central ECD loss was -0.1% to 7.5%, which was largely different among previous studies. We speculate that it is still challenging to exactly determine the ECD in some eyes with progressive keratoconus, as a result of the presence of apical scarring and/or a steep curvature of the cornea.…”

Section: Discussionmentioning

confidence: 99%

“…22 In this study, we found no significant changes in the peripheral CV or HEX after CXL, which was the same as previous studies with no significant changes in the central CV or HEX. 13,15,[17][18][19]21 The cellular stress levels of the cornea are chiefly reflected by the variations in the mosaic cell surface such as the presence of abnormally large cells and the deviation from their hexagonal shape. We previously reported that this device has provided good repeatability of the peripheral ECD, CV, and HEX measurements in eyes implanted with phakic intraocular lenses.…”

Section: Discussionmentioning

confidence: 99%

Effect of Corneal Cross-linking on Endothelial Cell Density and Morphology in the Peripheral Cornea.

Goukon

Kamiya

Takahashi

et al. 2020

Preprint

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BACKGROUND: To compare the endothelial cell density and morphology in the peripheral cornea before and after corneal cross-linking (CXL).METHODS: This study evaluated twenty eyes of 20 patients who were treated with standard CXL for progressive keratoconus. Preoperatively and 3 months postoperatively, we compared the corneal endothelial cell density (ECD), the coefficient of variation in cell size (CV), and the percentage of hexagonal cells (HEX), in the peripheral regions of the cornea, using a non-contact specular microscope (EM-3000, Tomey). RESULTS: All keratoconic eyes in this series were measurable in the peripheral regions. No significant differences were found in the peripheral ECD preoperatively and 3 months postoperatively at each point (Wilcoxon signed-rank test, superior, p=0.14, nasal superior, p=0.16, temporal superior, p= 0.35, inferior, p=0.27, nasal inferior, p=0.24, temporal inferior, p=0.10). The mean percentage of the ECD loss was 2.3%, 1.6%, 1.5%, 2.4%, 1.1%, and 2.2%, respectively. No significant differences in the peripheral CV or HEX were found preoperatively and 3 months postoperatively at each point.CONCLUSIONS: Standard CXL does not cause significant changes in endothelial cell density, polymegethism, or polymorphism, in the peripheral regions of the cornea. It is suggested that CXL is a less invasive surgical approach for progressive keratoconus, even in terms of peripheral endothelial cells.TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trial Registry (000031162).

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Accelerated versus conventional corneal collagen cross-linking in patients with keratoconus: an intrapatient comparative study

Cited by 49 publications

References 33 publications

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Effect of corneal cross-linking on endothelial cell density and morphology in the peripheral cornea

Effect of Corneal Cross-linking on Endothelial Cell Density and Morphology in the Peripheral Cornea.

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