Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: Results of a multicenter Phase III study

Sanguineti, Giuseppe; Richetti, A.; Bignardi, Mario; Corvò, Renzo; Gabriele, P.; Sormani, Maria Pia; Antognoni, Paolo

doi:10.1016/j.ijrobp.2004.07.682

Cited by 80 publications

(62 citation statements)

References 36 publications

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“…Experiments on animal tumors [2][3][4]16], retrospective clinical studies [6], and phase III trials on head-and-neck cancer [11,19] demonstrate that shortening overall treatment time of fractionated irradiation may increase local tumor control rates considerably. It is generally thought that fast repopulation is the major cause for this time factor.…”

Section: Discussionmentioning

confidence: 99%

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

2007

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Section: Discussionmentioning

confidence: 99%

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

2007

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“…Altered fractionation (AF) treatments have been widely studied in HNC to minimize the effect of tumor repopulation [17,18,19,20]. They are based on the radiobiological concept of increasing the tumor control rate when the same dose is delivered over a shorter time; AF consists of shortening RT duration or increasing the total RT dose, leaving the treatment time unchanged, in order to counteract tumor cell repopulation.…”

Section: State Of the Artmentioning

confidence: 99%

“…Patients who benefit more from adjuvant therapies are those with high-risk features [5,9,10,11,12,13,14,15,16,17,18,19,20,21]. …”

Section: State Of the Artmentioning

confidence: 99%

Postoperative Therapy in Head and Neck Cancer: State of the Art, Risk Subset, Prognosis and Unsolved Questions

et al. 2011

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Head and neck cancer may be easily controlled at early stages, but resectable locally advanced disease often relapses at T and N sites. Therefore, adequate adjuvant treatment is of crucial importance for improving local control and/or survival. Unfortunately, little data are available on the adjuvant setting. Adjuvant radiotherapy is regarded as a standard approach for patients with locally advanced radically resected head and neck cancer, while postoperative chemotherapy alone cannot be considered outside of clinical trials. However, chemoradiotherapy is widely considered superior to radiotherapy in patients at a high risk of relapse and may be considered the standard treatment in this population. In this respect, in the last few decades, there has been a growing interest due to the emerging data on both tumor biology and clinical trials. Several pathological and molecular factors, affecting behavior and head and neck cancer prognosis, could allow for a better selection of postoperative treatment. More recently, new prognostic and predictive factors were identified, including biomolecular aspects, human papillomavirus infection and lifestyle. The integration of these new factors deserves dedicated clinical studies, but the available knowledge already allows some deductive hypotheses. We performed a review of the literature to analyze the role of therapy in the postoperative setting and to discuss both the possibility of a different approach to each class of risk and the unsolved question for which randomized trials are warranted.

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“…Im Konsens mit der Literatur erwies sich dieses Zeitintervall als prognostisch relevant für alle Endpunkte. Letztlich basiert die Rationale hyperfraktionierter Therapieprotokolle in der klinischen Praxis auf der radiobiologischen Bedeutung dieses Zeitintervalls [3,4,11,17,19,20,28].…”

Section: Diskussionunclassified

Prognostische Wertigkeit der Zeitparameter in der adjuvanten Radiotherapie von HNO–Tumoren

Dietl

Schäfer²,

Kölbl

2005

Strahlenther Onkol

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Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: Results of a multicenter Phase III study

Cited by 80 publications

References 36 publications

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

Initially Accelerated Fractionation of the R1H Tumor of the Rat Increases Local Tumor Control and Might Reduce Impact of Overall Treatment Time

Postoperative Therapy in Head and Neck Cancer: State of the Art, Risk Subset, Prognosis and Unsolved Questions

Prognostische Wertigkeit der Zeitparameter in der adjuvanten Radiotherapie von HNO–Tumoren

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