Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol–chitosan hydrogel containing honey bee venom in diabetic rats

Amin, Mohamed A.; Abdel-Raheem, Ihab T.

doi:10.1007/s12272-013-0308-y

Cited by 85 publications

(41 citation statements)

References 71 publications

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“…that the hydrogels made of chitosan, poly(ethylene glycol) and polyvinylpyrrolidone could work as antimicrobial and scar preventive dressings. Moreover, chitosan‐based hydrogels are regarded as carriers to deliver the therapeutic drugs topically, such as vancomycin, peptide Ser‐Ile‐Lys‐Val‐Ala‐Val, melatonin, tigecycline, bFGF, and honey bee . These drugs have at least one of following functions: (1) antibacterial; (2) anti‐inflammatory; (3) angiogenesis; and (4) the promotion of fibroblast proliferation, thus, facilitating to skin repair.…”

Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…This is primarily associated with a series of macrovascular and microvascular alteration that leads to many systemic complications [4,6]. These systemic complications will result in delayed wound healing that may eventually lead to limb amputation [4,7]. Nontraumatic lower limb amputation is one of the worst complications of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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“…The incorporation of bee venom into a PVA/chitosan hydrogel promoted the healing of chronic wounds in diabetic rats by inducing the production of collagen and decreasing the expression of IL‐6 after topical transfer. The progressive release of bee venom from the gel led to the healing of murine wounds over 21 days of treatment (Amin & Abdel‐Raheem, ).…”

Section: Hydrogels For Treatment Of Diabetes‐related Conditionsmentioning

confidence: 99%

Advanced hydrogels for treatment of diabetes

Reyes-Martínez

Ruíz-Pacheco²,

Flores-Valdéz

et al. 2019

J Tissue Eng Regen Med

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Diabetes mellitus is a chronic disease characterized by high levels of glucose in the blood, which leads to metabolic disorders with severe consequences. Today, there is no cure for diabetes. The current management for diabetes and derived medical conditions, such as hyperglycemia, cardiovascular diseases, or diabetic foot ulcer, includes life style changes and hypoglycemia‐based therapy, which do not fully restore euglycemia or the functionality of damaged tissues in patients. This encourages scientists to work outside their boundaries to develop routes that can potentially tackle such metabolic disorders. In this regard, acellular and cellular approaches have represented an alternative for diabetics, although such treatments still face shortcomings related to limited effectiveness and immunogenicity. The advent of biomaterials has brought significant improvements for such approaches, and three‐dimensional extracellular matrix analogs, such as hydrogels, have played a key role in this regard. Advanced hydrogels are being developed to monitor high blood glucose levels and release insulin, as well as serve as a therapeutic technology. Herein, the state of the art in advanced hydrogels for improving treatment of diabetes, from laboratory technology to commercial products approved by drug safety regulatory authorities, will be concisely summarized and discussed.

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Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol–chitosan hydrogel containing honey bee venom in diabetic rats

Cited by 85 publications

References 71 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Advanced hydrogels for treatment of diabetes

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