In this paper, we explore, extend and simplify the localization of the description ability of the well-established MPEG-7 (Scalable Colour Descriptor (SCD), Colour Layout Descriptor (CLD) and Edge Histogram Descriptor (EHD)) and MPEG-7-like (Color and Edge Directivity Descriptor (CEDD)) global descriptors, which we call the SIMPLE family of descriptors. Sixteen novel descriptors are introduced that utilize four different sampling strategies for the extraction of image patches to be used as points of interest. Designing with focused attention for content-based image retrieval tasks, we investigate, analyse and propose the preferred process for the definition of the parameters involved (point detection, description, codebook sizes and descriptors' weighting strategies). The experimental results conducted on four different image collections reveal an astonishing boost in the retrieval performance of the proposed descriptors compared to their performance in their original global form. Furthermore, they manage to outperform common SIFTand SURF-based approaches while they perform comparably, if not better, against recent state-of-the-art methods that base their success on much more complex data manipulation.