Accelerating the aesthetic benefit of wound healing by triterpene

Metelmann, H.‐R.; Brandner, Johanna M.; Schumann, Hauke; Bross, Felix; Hoffmann, M.; Podmelle, Fred

doi:10.1016/j.jcms.2011.07.020

Cited by 22 publications

(33 citation statements)

References 10 publications

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“…In order to evaluate whether the nature of the used oil has an impact on betulin permeation, we chose for this study sunflower oil which is of medium polarity and has already been proven to enhance wound healing [15,16]. As second triglyceride with similar polarity but higher solubility, MCT was selected.…”

Section: Resultsmentioning

confidence: 99%

“…Comparing flux and viscosity shows that there is a clear relationship but not a full correlation as rheological measurements characterize the macroviscosity of a system whereas diffusion and release are influenced by the microviscosity [29]. Interestingly, the observed order in the permeation flux with the different oils differs from the release rate measured from equivalent oleogels [16]. This indicates that although the stratum corneum as the predominant skin barrier has been removed for these experiments there is a specific interaction between the oil which is used as vehicle and the injured skin.…”

Section: Resultsmentioning

confidence: 99%

“…Wounds and injured skin of several types have been examined: actinic keratoses, surgical skin lesions and necrotizing herpes zoster [14,15,16,17], and the benefit of this dry TE in wound healing has been underlined. Besides, the molecular mechanism and ex vivo wound-healing models have been investigated [18].…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study was to predict the wound-healing effect of the w/o foams containing TE of the outer bark of birch by comparing the betulin permeation from these novel formulations to the permeation of betulin from oleogels which have already been characterized with respect to their ability which have proven to promote wound healing [16]. To this end the skin permeation rates of betulin, the main constituent of the TE, from oleogels, w/o creams and w/o foams were compared.…”

Section: Introductionmentioning

confidence: 99%

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Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams

Färber

Daniels²

2016

Skin Pharmacol Physiol

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Triterpenes of the outer bark of birch are known to improve wound healing. An oleogel with these triterpenes as active principle is approved by the European Medicines Agency. As foams can be applied without touching the skin, they might be an advantageous application form. A comparable wound-healing effect can be expected when the permeation flux of the triterpenes from different types of formulations, namely oleogels, water-in-oil emulsions and water-in-oil foams, is similar. The tested formulations were based on three lipids (medium-chain trigylcerides, sunflower oil and paraffin) which differ in their polarity and solvent power for the triterpenes. Infinite dose permeation experiments were performed using porcine skin which was injured by either tape stripping or skin grafting. The results showed that steady-state permeation flux and lag time depend clearly on the depth of the skin lesion. Moreover, it was substantially affected by the lipid used as basis for the different formulations. In contrast, the different formulation types showed a comparable permeation behaviour leading to the conclusion that all formulation types can be used alike for the treatment of wounds, and the results that have already been obtained with oleogels can be directly translated to the foam with its superior use properties.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams

Färber

Daniels²

2016

Skin Pharmacol Physiol

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“…grade 2 on a scale of 1 (none) to 10 (severe), was found in only 1 patient on the Mepilex control side; pruritus was reported by 1 patient on the Oleogel-S10 side (grade 3) and 2 patients on the control side (grades 2 and 3). The results of the aesthetic outcome assessment after 3 months were published separately [22]. …”

Section: Resultsmentioning

confidence: 99%

Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions

Metelmann

Brandner

Schumann

et al. 2014

Skin Pharmacol Physiol

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The acceleration of wound healing is a major surgical concern. A triterpene extract from birch bark (Betulae cortex) experimentally enhances keratinocyte differentiation in vitro and accelerates wound healing ex vivo. We conducted an open, blind-evaluated, controlled, prospective, randomized (1:1) phase II clinical trial in patients requiring split-thickness skin graft transplantation at two university hospitals in Germany. Donor sites on the upper legs were covered with a moist silicone-coated dressing. Oleogel-S10 ointment containing 10% birch bark extract was randomly applied to the distal or proximal half of the wound, with the other half serving as an intraindividual control, for 14 days after the skin graft surgery. The primary efficacy variable was faster reepithelialization as determined from macrophotographs by independent, blinded experts. Twenty-four patients were randomized and completed the trial. After the 14-day test period, the planned interim analysis revealed a highly significant (p 0.0001) superiority of Oleogel-S10 in the primary efficacy variable and the trial was terminated early due to ethical concerns. The treatment side was also better reepithelialized and more similar to normal skin after 3 months. In conclusion, Oleogel-S10 significantly accelerated reepithelialization at split-thickness skin graft donor sites. Treatment with Oleogel-S10 was safe and well tolerated. i 2014 S. Karger AG, Basel

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Wundbehandlung

Daeschlein¹,

Müller-Debus²

2014

Lasermedizin in Der Ästhetischen Chirurgie

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Accelerating the aesthetic benefit of wound healing by triterpene

Cited by 22 publications

References 10 publications

Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams

Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams

Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions

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