Due to the difficulty in deducing the corresponding relationship between results and parameter settings of multiple phases sectionalized modulation (MPSM) jamming, a problem occurs when obtaining the optimal local suppression jamming effect, which limits the practical application of MPSM jamming. The traditional method struggles to meet the requirements by setting fixed parameters or random parameters. Therefore, an optimization algorithm for MPSM jamming based on particle swarm optimization (PSO) is proposed in this study to produce the optimal local suppression jamming effect and determine its corresponding parameter settings. First, we analyzed the relationship between the degree of mismatch and local suppression jamming effect. Then, we set appropriate fitness function and fitness value. Finally, we used PSO to calculate parameter settings of a section situation and phase situation, which minimizes the fitness function and fitness value. The optimization algorithm avoids the tremendous computation of traversing all parameter settings, is stable, the results are repeatable, and the algorithm provides the optimal local suppression jamming effect under different conditions. The simulation experiments demonstrate the feasibility and effectiveness of the optimization algorithm.