Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold

Razali, Nur Adila Mohd; Lin, Wei-Chih

doi:10.1016/j.mtbio.2022.100347

Cited by 18 publications

(16 citation statements)

References 53 publications

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“…Previous study reported a similar trend, noting that entanglement of the nanofiber with hydrogel networks resulted in a decrease in the porosity of the scaffold. [ 27 ] In addition, the dissolution of GMs significantly increased the porosity of hydrogel (Figure S5, Supporting Information). Figure 3e shows the swelling behavior of the nanofiber composite microchannel‐containing hydrogels with different PGF contents.…”

Section: Resultsmentioning

confidence: 99%

Nanofiber Composite Microchannel‐Containing Injectable Hydrogels for Cartilage Tissue Regeneration

Liu,

Tang,

Huang

et al. 2023

Adv Healthcare Materials

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Articular cartilage tissue is incapable of self‐repair and therapies for cartilage defects are still lacking. Injectable hydrogels have drawn much attention in the field of cartilage regeneration. Herein, the novel design of nanofiber composite microchannel‐containing hydrogels inspired by the tunnel‐piled structure of subway tunnels is proposed. Based on the aldehydized polyethylene glycol/carboxymethyl chitosan (APA/CMCS) hydrogels, thermosensitive gelatin microrods (GMs) are used as a pore‐forming agent, and coaxial electrospinning polylactic acid/gelatin fibers (PGFs) loaded with kartogenin (KGN) are used as a reinforcing agent and a drug delivery system to construct the nanofiber composite microchannel‐containing injectable hydrogels (APA/CMCS/KGN@PGF/GM hydrogels). The in situ formation, micromorphology and porosity, swelling and degradation, mechanical properties, self‐healing behavior, as well as drug release of the nanofiber composite microchannel‐containing hydrogels are investigated. The hydrogel exhibits good self‐healing ability, and the introduction of PGF nanofibers can significantly improve the mechanical properties. The drug delivery system can realize sustained release of KGN to match the process of cartilage repair. The microchannel structure effectively promotes bone marrow mesenchymal stem cell (BMSC) proliferation and ingrowth within the hydrogels. In vitro and animal experiments indicate that the APA/CMCS/KGN@PGF/GM hydrogels can enhance the chondrogenesis of BMSCs and promote neocartilage formation in the rabbit cartilage defect model.

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Section: Resultsmentioning

confidence: 99%

Nanofiber Composite Microchannel‐Containing Injectable Hydrogels for Cartilage Tissue Regeneration

Liu,

Tang,

Huang

et al. 2023

Adv Healthcare Materials

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“…A biocompatible porcine acellular dermal matrix hydrogel blended with vancomycin has been developed for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds [ 276 ]. A patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold has recently been proposed for skin tissue engineering [ 277 ]. The biocompatibility of the scaffold was proven by cytotoxicity and haemolysis studies.…”

Section: Antimicrobial Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Serrano‐Aroca

Cano-Vicent

Serra

et al. 2022

Materials Today Bio

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“…Nevertheless, to fulfill the diverse demands involved in the complex wound healing process, it is a request to develop ENMs with multiple functions including antibacterial and antioxidant activities. Therefore, ENMs with a defined three-dimensional framework could promote wound healing via integrated multiple functions, such as hemostasis, antibacterial activities, and anti-inflammatory properties. , For instance, Cai and co-authors constructed a sandwich-structured wound dressing to impact both the bactericidal effect and superior biocompatibility. Chen et al fabricated a curcumin-loaded sandwich-like nanofibrous membrane to accelerate wound healing.…”

Section: Introductionmentioning

confidence: 99%

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

Cai,

Zhang,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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With the increasing prevalence of microbial infections, which results in prolonged inflammation and delayed wound healing, the development of effective and safe antimicrobial wound dressings of multiple properties remains challenging for public health. Despite their various formats, the available developed dressings with limited functions may not fulfill the diverse demands involved in the complex wound healing process. In this study, multifunctional sandwich-structured electrospinning nanofiber membranes (ENMs) were fabricated. According to the structural composition, the obtained ENMs included a hydrophilic inner layer loaded with curcumin and gentamicin sulfate, an antibacterial middle layer consisting of bovine serum albumin stabilized silver oxide nanoparticles, and a hydrophobic outer layer. The prepared sandwich-structured ENMs (SNM) exhibited good biocompatibility and killing efficacy on Escherichia coli, Staphylococcus aureus, and Methicillin-resistant S. aureus (MRSA). In particular, transcriptomic analysis revealed that SNM inactivated MRSA by inhibiting its carbohydrate and energy metabolism and reduced the bacterial resistance by downregulating mecA. In the animal experiment, SNM showed improved wound healing efficiency by reducing the bacterial load and inflammation. Moreover, 16S rDNA sequencing results indicated that SNM treatment may accelerate wound healing without observed influence on the normal skin flora. Therefore, the constructed sandwich-structured ENMs exhibited promising potential as dressings to deal with the infected wound management.

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Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold

Cited by 18 publications

References 53 publications

Nanofiber Composite Microchannel‐Containing Injectable Hydrogels for Cartilage Tissue Regeneration

Nanofiber Composite Microchannel‐Containing Injectable Hydrogels for Cartilage Tissue Regeneration

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

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