Acceleration and circadian rhythm of eruption rates in the rat incisor

Chiba, M.; Tashiro, Tetsuo; Tsuruta, Masahiko; Eto, Kazuhiro

doi:10.1016/0003-9969(76)90046-7

Cited by 24 publications

(4 citation statements)

References 16 publications

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“…This result was also demonstrated in the present investigation, confirming previous published results (Chiba et al 1976;Ohshima et al 2005;Novaes et al 2009;Gomes et al 2010).…”

Section: Discussionsupporting

confidence: 96%

Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure

et al. 2011

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MMP-9 and MMP-2 are metalloproteinases which degrade the denatured collagen fibers. However, there is no report about roles of these MMPs in the odontogenic region of the adult rat incisor tooth under different eruption conditions. Male Wistar rats were divided in a normofunctional group (NF) in which their lower teeth remained in a normal eruption. In a hypofunctional group (HP) rats underwent shortening of their lower left incisor tooth every 2 days during 12 days. The eruption rate as well as the expression and activities of MMP-9 and MMP-2 were evaluated using imunohistochemistry and zymography. Although the shortening increased the eruption rate, no changes in the MMP-9 and MMP-2 were observed. We conclude that in adult rats, in opposite to development of tooth, the MMP-9 and MMP-2 present in the odontogenic region does not seem to play a direct role in the remodeling matrix, even after post-shortening procedures which to lead an acceleration of the eruption process in the incisor.

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“…This result was also demonstrated in the present investigation, confirming previous published results (Chiba et al 1976;Ohshima et al 2005;Novaes et al 2009;Gomes et al 2010).…”

Section: Discussionsupporting

confidence: 96%

Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure

et al. 2011

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“…All groups received water and food ad libitum and were maintained at a 12 hr light/dark cycle (06:30–18:30 hr) during the experimental period. All experiments were always performed in the morning to minimize circadian rhythm variation (Chiba et al, ).…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Cell Proliferation and Eruption Rate in the Rat Incisor

Gomes

Omar

Carmo

et al. 2013

The Anatomical Record

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The aim of this study was to further define the relationship between cell proliferation and the rate of tooth eruption in the rat incisor. Vinblastine is a drug that blocks cellular mitosis and was used to inhibit cell proliferation in the odontogenic region of rat incisors that were submitted to a shortening treatment or to higher masticatory forces. Male Wistar rats were divided into five groups: normofunctional (control group for incisor eruption), hypofunctional (incisor submitted to eruption acceleration), hyperfunctional (incisors under higher masticatory forces), hypofunctional with vinblastine and hyperfunctional with vinblastine. In incisors submitted to shortening procedures, a significant decrease in the eruption rate and cell proliferation was observed two days after vinblastine injection, suggesting that incisor eruption is dependent on cell proliferation. Anat

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“…1B). The shortening treatment, eruption rate estimate and animal's death (cervical deslocation) were always performed in the morning to avoid circadian rhythm variation (Chiba et al 1976). …”

Section: Treatmentsmentioning

confidence: 99%

Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure

et al. 2010

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MT1-MMP and TIMP-2 are well known for their roles in remodelling of extracellular matrix components. However, reports are emerging on the involvement of these molecules in cell kinetics. In the rat incisor tooth, a shortening treatment increases the eruption and cell proliferation rates. However, the role of MT1-MMP and TIMP-2 proteins in these processes is still to be evaluated. Male Wistar rats were divided in two groups. In the normofunctional group (NF) the lower teeth of the rats remained in a normal eruption process. In the hypofunctional group (HP) rats their lower left incisor tooth was shortened every 2 days during 12 days. The eruption rate was estimated during the shortening period and MT1-MMP, TIMP-2 and Ki-67 protein expression from the odontogenic region was measured after the treatment. In HP groups an increase in eruption rate, and in MT1-MMP/TIMP-2 and Ki-67 expression were observed. We conclude that there is a relationship between the increase in eruption rate, and in levels of MT1-MMP, TIMP-2 and Ki-67 in the HP group. This suggests that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth.

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Acceleration and circadian rhythm of eruption rates in the rat incisor

Cited by 24 publications

References 16 publications

Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure

Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure

Relationship Between Cell Proliferation and Eruption Rate in the Rat Incisor

Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure

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