A lack of understanding about the effect of microorganism inoculation on compost production and relatively expensive downstream processing are the main obstacles towards an economic compost production. Our work tries to fill this gap. For this, influence of inoculation on the composting of organic fraction of municipal solid waste (OFMSW) to produce compost with higher agronomic value was evaluated. Three similar aerated bioreactors (A, B and C) with the same size and shape in laboratory scale designed. Reactor A was inoculated with the Aspergillus niger IBRC-M 30095, reactor B was inoculated with old compost and reactor C was used as a control. During the composting process temperature, moisture, pH, and electrical conductivity (EC) were evaluated. Also, the ratio of carbon to nitrogen (C/N) and germination index (GI) were measured in during process to evaluate compost maturity. The results of this study showed that the C/Ns decreased to about 63.37%, 59.6% and 46% for bioreactors B, A and control, respectively. Also maximum GI and temperature reached to about 138% and 59°C in reactor B. Furthermore, our results showed that inoculation with this microorganism reduces process time to 18 days that is better than the results of other researchers and thus results in cost savings. However, we think, Aspergillus niger is appropriate candidate for compost production as a model.