Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study

Carmichael, Owen; Kuller, Lewis H.; López, Oscar L.; Thompson, Paul M.; Dutton, Rebecca A.; Lu, Amanda; Lee, S.E.; Lee, J.Y.; Aizenstein, Howard J.; Meltzer, Carolyn C.; Liu, Y.; Toga, Arthur W.; Becker, James T.

doi:10.1016/j.neurobiolaging.2006.06.016

Cited by 27 publications

(24 citation statements)

References 36 publications

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“…In agreement with prior reports14, 43, we found a significant effect of age on the shape and size of the lateral ventricles. This effect is most pronounced in the frontal horns perhaps as the result of structural changes in one or more tissue classes in the frontal lobes44–47.…”

Section: Discussionsupporting

confidence: 93%

Hippocampal Atrophy and Ventricular Enlargement in Normal Aging, Mild Cognitive Impairment (MCI), and Alzheimer Disease

Apostolova

Green²,

Babakchanian

et al. 2012

Alzheimer Disease &Amp; Associated Disorders

292

224

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Alzheimer's disease (AD) is the most common type of dementia worldwide. Hippocampal atrophy and ventricular enlargement have been associated with AD but also with normal aging. We analyzed 1.5T brain MRI data from 46 cognitively normal elderly (NC), 33 mild cognitive impairment (MCI) and 43 AD subjects. Hippocampal and ventricular analyses were conducted with two novel semi-automated segmentation approaches followed by the radial distance mapping technique. Multiple linear regression was used to assess effects of age and diagnosis on hippocampal and ventricular volumes and radial distance. Additional 3D map correction for multiple comparisons was conducted with permutation testing. As expected, most significant hippocampal atrophy and ventricular enlargement were seen in the AD vs. NC comparison. MCI subjects showed intermediate levels of hippocampal atrophy and ventricular enlargement. Significant effects of age on hippocampal volume and radial distance were seen in the pooled sample as well as in the NC and AD groups considered separately. Age-associated differences were detected in all hippocampal subfields and the frontal and body/occipital horn portions of the lateral ventricles. Aging affects both the hippocampus and lateral ventricles independent of AD pathology and should be included as covariate in all structural hippocampal and ventricular analyses when possible.

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Section: Discussionsupporting

confidence: 93%

Hippocampal Atrophy and Ventricular Enlargement in Normal Aging, Mild Cognitive Impairment (MCI), and Alzheimer Disease

Apostolova

Green²,

Babakchanian

et al. 2012

Alzheimer Disease &Amp; Associated Disorders

292

224

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show abstract

“…The bottom rows show the significance of these reductions, revealing highly significant atrophy in AD but a more anatomically restricted atrophic pattern in MCI. In MCI (b), atrophy is most prominent in the left hippocampus; as expected (Carmichael et al, 2007a, b), ventricular expansion is also substantial. When MCI is compared with AD (c), additional temporal lobe degeneration is evident.…”

Section: Figuresupporting

confidence: 64%

Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects

Hou¹,

Leow²,

Parikshak³

et al. 2008

NeuroImage

329

288

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In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. Jacobian determinant maps were created, revealing the 3D profile of local volumetric expansion and compression. We compared the anatomical distribution of atrophy in 165 AD patients (age: 75.6 ± 7.6 years), 330 MCI subjects (74.8 ± 7.5), and 181 controls (75.9 ± 5.1). Brain atrophy in selected regions-of-interest was correlated with clinical measurements - the sum-of-boxes clinical dementia rating (CDR-SB), mini-mental state examination (MMSE), and the logical memory test scores - at voxel level followed by correction for multiple comparisons. Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects. Over half of the AD and MCI subjects carried the ApoE4 (apolipoprotein E4) gene, which increases risk for AD; they showed greater hippocampal and temporal lobe deficits than non-carriers. ApoE2 gene carriers - 1/6 of the normal group - showed reduced ventricular expansion, suggesting a protective effect. As an automated image analysis technique, TBM reveals 3D correlations between neuroimaging markers, genes, and future clinical changes, and is highly efficient for large-scale MRI studies.

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“…Ventral striatum and hippocampal volumes are associated with incident AD over a 4.5-year follow-up period [43], and hippocampal volume and MRI-infarcts are independent predictors of incident dementia [67]. Ventricular expansion is faster in subjects who develop MCI [70], and these rates can be increased by diabetes mellitus and hypertension [71]. Our data are important in this context because we found that hypertension and the presence of markers of cerebrovascular disease were significant predictors of the volumes of the mesial temporal lobe and the precuneus.…”

Section: Discussionmentioning

confidence: 99%

Voxel Level Survival Analysis of Grey Matter Volume and Incident Mild Cognitive Impairment or Alzheimer’s Disease

Zeifman

Eddy

López

et al. 2015

JAD

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The purpose of this study was to identify, at the voxel level, brain regions associated with the time to develop mild cognitive impairment (MCI) or Alzheimer’s disease (AD) from normal cognition. We analyzed incident MCI (n = 58) or AD (n = 151) in 292 cognitively normal participants in the Cardiovascular Health Study–Cognition Study (mean age = 79.2±3.6 years). We used segmented, modulated grey matter maps from 3D (spoiled gradient echo) MRI scans obtained in 1998/99 (with clinical follow-up through 2012) that were smoothed with a 3-D 4 mm Gaussian filter. We fit approximately 1.92 million voxel-level Cox proportional hazard models to examine the grey matter volume effect on time to event, adjusting for age, sex, and diabetes. We used the significance threshold of p < 0.005 with contiguity threshold of at least 68 voxels (false detection probability <2.5 × 10−8). Areas within the mesial temporal lobe (MTL), anterior temporal lobe, hippocampus, and posterior cingulate gyrus were associated with time to MCI or AD. The presence of white matter lesions (a marker of small vessel disease in the brain) was associated with the volumes of the MTL and precuneus; MRI-identified infarcts also predicted MTL volume. These findings are important because we identified critical brain regions that predict a person’s increased likelihood of developing MCI or AD over a decade prior to the onset of clinical symptoms; these critical brain regions were themselves affected by the presence of vascular disease.

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Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study

Cited by 27 publications

References 36 publications

Hippocampal Atrophy and Ventricular Enlargement in Normal Aging, Mild Cognitive Impairment (MCI), and Alzheimer Disease

Hippocampal Atrophy and Ventricular Enlargement in Normal Aging, Mild Cognitive Impairment (MCI), and Alzheimer Disease

Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects

Voxel Level Survival Analysis of Grey Matter Volume and Incident Mild Cognitive Impairment or Alzheimer’s Disease

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