Acceleration of Chronic Wound Healing With Galenic cream of Snail Seromucoid, Durian Peel Extract Polysaccharides And chitosan

Abstract

The treatment of chronic wounds take a relatively long time so a wound care process or wound management using traditional or modern medical therapy is needed. Objective: The objective of this study is to investigate the effectiveness of galenic cream of snail seromucoid, durian peel extract and chitosan as anti-inflammatories in vitro and in vivo for chronic wound healing. Theoretical Framework: Snail seromucoid, durian peel extract, and chitosan and their combinations can be developed as galenic cream preparations for the treatment of chronic wounds Method: The research method was based on the experimental design with the research stages covering bioformulation of galenic cream preparations of snail seromucoid, durian peel extract, and chitosan as well as testing the quality of galenic preparations physically, chemically, and microbiologically. Results and Discussion: Bioformulation galenic preparation of 2% snail seromucoid, 2% polysaccharide of durian peel extract; 2% chitosan and their combination with ratio 1:1:1 according to the requirements of Food and Drug Monitoring Agency, Republic of Indonesia No. 32 of 2019, it meets the requirements for the quality test of cream preparations in a physicochemical manner including pH, antioxidant activity, dispersion, and adhesion and microbiologically includes Total Plate Number, Yeast Mold Number, and no microbial pathogens Staphylococcus aureus, Pseudomonas aeruginosa,and Candida albicans. Research Implications: The galenic of 2% snail seromucoid, 2% polysaccharide of durian peel extract and 2% chitosan 2% is effective as an anti-inflammatory cream. The results of this study indicate implications for the acceleration of chronic wound healing rates. Originality/Value: Harti et al's research results of the Basic Research Program Higher Education, Ministry of Research and Technology Republic of Indonesia, 2019-2022 fiscal years and the Simple Patent No. S00202010479 showed a synergistic effect of bioactive compounds seromucoid snails and chitosan as biological response modifiers or bioimmunostimulators and antimicrobial agents so that it can be developed as anti-inflammatory galenic preparations