Acceleration of crystal growth rates: an unexpected effect of tailor-made additives

Dowling, Richard J.; Davey, Roger J.; Curtis, Robin; Han, Guangjun; Poornachary, Sendhil K.; Chow, Pui Shan; Tan, Reginald B. H.

doi:10.1039/c0cc00336k

Cited by 92 publications

(155 citation statements)

References 29 publications

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“…10 to be determined at 25 C. This conrmed the lack of a non-solvated form and dened the composition of stability of both the hemihydrate and the ethanolate. 41) at the lower supersaturation ratio of 1.58. 10.…”

Section: Molecular Complexitymentioning

confidence: 92%

Crystal nucleation from solutions – transition states, rate determining steps and complexity

2015

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This introductory paper offers a contemporary view of crystal nucleation. We begin with a molecular interpretation of the transition state and then revisit the use of classical nucleation theory as a means of obtaining molecular scale information from kinetic data. Traditional physical organic chemistry has always utilised the combination of kinetics and thermodynamics in order to gain insight over reaction pathways. Here we demonstrate for the cases of sucrose and p-aminobenzoic acid how solution chemistry, crystallography and kinetics come together to provide self-consistent pictures of the molecular scale processes occurring during nucleation. In this and a number of other systems desolvation of specific functional groups is highlighted as the rate determining step. Finally we move on to discuss the question of complexity, both from a phase and molecular perspective.

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Section: Molecular Complexitymentioning

confidence: 92%

Crystal nucleation from solutions – transition states, rate determining steps and complexity

2015

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“…This may be interpreted based on pH-induced proton transfer 4,19 of an amino acid. In acidic environment, the COO − groups of alanine molecules in solution are protonated to form alanine cations (CH 3 CH(NH 3 + )COOH), which may be the favorable building units of DL-alanine crystal because they can be driven to DL-alanine −c end more readily due to greater Coloumbic force.…”

Section: In Solutionmentioning

confidence: 99%

Strong Additive–Surface Interaction Leads to the Unusual Revival of Growth at Solvent-Poisoned Faces ofdl-Alanine Crystal

Han

Tan

2012

Crystal Growth & Design

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The effects of various anions and cations dissociated from a spectrum of inorganic salts on the growth of DL-alanine polar c-axis have been systematically investigated using in situ microscopic observations on single seed crystals. Surprisingly, it is observed that both the polar −c and +c ends of DLalanine c-axis undergo a revival of solvent-poisoned dead growth in the presence of every one of the additives used in this study. Furthermore, it is found that divalent ions (e.g., Mg 2+ and SO 4 2− ) promote the growth along DL-alanine c-axis more effectively than univalent ions (e.g., Na + and Cl − ). Such an ion-induced growth acceleration of DL-alanine c-axis, contrary to the usual understanding, particularly shows an unusual case where important Coulombic interaction between additive and crystal surface can actually favor face growth. This interesting phenomenon is interpreted at the molecular level, with the role of surface roughening particularly highlighted.

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“…Figure 32.14 shows the effect of an impurity on the growth and dissolution rate of a crystalline compound [65]. There are reports that additives lead to increased growth rates [66]. The more of the impurity is present, the more the growth rate is reduced.…”

Section: Crystal Growthmentioning

confidence: 99%

Fundamentals of Industrial Crystallization

Horst

Schmidt

Ulrich

2015

Handbook of Crystal Growth

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Acceleration of crystal growth rates: an unexpected effect of tailor-made additives

Cited by 92 publications

References 29 publications

Crystal nucleation from solutions – transition states, rate determining steps and complexity

Crystal nucleation from solutions – transition states, rate determining steps and complexity

Strong Additive–Surface Interaction Leads to the Unusual Revival of Growth at Solvent-Poisoned Faces ofdl-Alanine Crystal

Fundamentals of Industrial Crystallization

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