Acceleration of Fracture Healing: a Comparison Between Clinical Available Low Intensity Pulsed Ultrasound (LIPUS) and a Novel BiModal Acoustic Signal System

Machado, Priscilla; Forsberg, Flemming; Li, Jingzhi; Blackman, Rachel; Liu, Ji‐Bin; Kepler, Christopher C.; Fang, Taolin; Muratore, Robert; Winder, Jason; Winder, Alan A.

doi:10.1109/ultsym.2019.8926199

Cited by 1 publication

(2 citation statements)

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“…Each clinical case requires specific treatments, e.g., fracture healing, distraction osteogenesis, or tissue engineering. In recent years, an extensive literature has developed on novel technologies to increase the regeneration rates and efficiency during clinical procedures [ 6 , 7 , 8 , 9 ]. For instance, Hatefi et al [ 6 ] developed a distraction device based on a lead screw translation mechanism to support a continuous distraction of several craniomaxillofacial areas.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, Hatefi et al [ 6 ] developed a distraction device based on a lead screw translation mechanism to support a continuous distraction of several craniomaxillofacial areas. A novel acoustic signal system, which employs ultrasound shear stress, was recently designed and tested in vivo by Machado et al [ 7 ] to reduce bone fracture healing time. Regarding tissue engineering, the research is mainly focused on the optimization and manufacture of scaffolds or implants, which guarantee the cell infiltration and differentiation, such as the development of nanocomposite magnetic scaffolds carried out by Russo et al [ 8 ] or the hybrid HA/PCL coaxial scaffolds manufactured by robocasting by Paredes et al [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Real-Time Wireless Platform for In Vivo Monitoring of Bone Regeneration

Blázquez-Carmona

Sánchez-Raya

Mora‐Macías

et al. 2020

Sensors

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For the monitoring of bone regeneration processes, the instrumentation of the fixation is an increasingly common technique to indirectly measure the evolution of bone formation instead of ex vivo measurements or traditional in vivo techniques, such as X-ray or visual review. A versatile instrumented external fixator capable of adapting to multiple bone regeneration processes was designed, as well as a wireless acquisition system for the data collection. The design and implementation of the overall architecture of such a system is described in this work, including the hardware, firmware, and mechanical components. The measurements are conditioned and subsequently sent to a PC via wireless communication to be in vivo displayed and analyzed using a developed real-time monitoring application. Moreover, a model for the in vivo estimation of the bone callus stiffness from collected data was defined. This model was validated in vitro using elastic springs, reporting promising results with respect to previous equipment, with average errors and uncertainties below 6.7% and 14.04%. The devices were also validated in vivo performing a bone lengthening treatment on a sheep metatarsus. The resulting system allowed the in vivo mechanical characterization of the bone callus during experimentation, providing a low-cost, simple, and highly reliable solution.

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