Acceleration of Fresh Fracture Repair Using the Sonic Accelerated Fracture Healing System (SAFHS): A Review

Warden, Stuart J.; Bennell, Kim L; McMeeken, Joan; Wark, John D.

doi:10.1007/s002230010031

Cited by 80 publications

(60 citation statements)

References 29 publications

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“…It has been reported that application of low-intensity pulsed ultrasound stimulation (LIPUS) promotes fracture healing and LIPUS has been clinically applied in the orthopaedic field [2,3], where positive effects of LIPUS on fracture healing of long bone were clearly concluded to reduce the time frame of clinical and radiographic healing by 38% [4]; however, effects of LIPUS on bone regeneration of flat bones in the cranial-maxillofacial area have not been abundantly documented although promotion of reossification ratio in rat noncritical-sized parietal bone defects by LIPUS or by low magnitude and high frequency mechanical stimuli has been recently reported [5,6] and although some clinicians have already performed LIPUS for bone augmentations in this area. Effects of LIPUS on bone regeneration in the cranial-maxillofacial should be carefully evaluated in animal experiments prior to its clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Effects of low intensity pulsed ultrasound stimulation on bone regeneration in rat parietal bone defect model

Chen¹,

Jia²,

Noritake³

et al. 2013

OJRM

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Purpose: Low intensity pulsed ultrasound stimulation (LIPUS) has been clinically applied to promote bone fracture healing in the orthopedic field. Thus, it is likely that LIPUS also stimulates bone regeneration in bone defects in the cranial-maxillofacial area. However, this has not been clearly proved. Furthermore, optimal time point and period of the application after the surgery has not been reported. The purpose of the present study was to evaluate the effect of LIPUS on bone regeneration in the rat parietal bone defects especially focusing on time and period of the application. Materials and Methods: Eighteen Wistar rats (14 weeks old) were divided into 6 groups: 5 experimental groups and a control group. Bone defect of 5 mm diameter was prepared on each side of the parietal bone and customized gelatin membranes were placed over the bone defects. LIPUS (160 mW/cm 2 , 15 min/day) was applied to the defect area with an active transducer externally in the experimental groups according to the schedules of the applications: Group 1 (day 6 -12), group 2 (day 13 -19), group 3 (day 20 -26), group 4 (day 6 -19) and group 5 (day 6 -26). All the animals were sacrificed at 28 days. The defects were analyzed with micro CT and then histologically. Results: In Group 1, new bone formation was significantly promoted and the newly-formed bone was thick and matured compared to the one of the control group. In other experimental groups there were tendencies of stimulation of new bone formation; however, they were not statistically significant. Discussion and Conclusion: The present study demonstrated that amount of new bone formation in the bone defect depended on the time and period of LIPUS application. It has been suggested that application of LIPUS at an early healing period, the second week after the surgery, effectively accelerated new bone formation.

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Section: Introductionmentioning

confidence: 99%

Effects of low intensity pulsed ultrasound stimulation on bone regeneration in rat parietal bone defect model

Chen¹,

Jia²,

Noritake³

et al. 2013

OJRM

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“…While earlier reports showed that LIPUS enhances and accelerates repair of fractured bones (Heckman et al, 1994;Cook et al, 1997;Kristiansen et al, 1997;Hadjiargyrou et al, 1998;Mayr et al, 2000;Warden et al, 2000;Nolte et al, 2001;Jingushi et al, 2007;Walker et al, 2007;Griffin et al, 2008;Busse et al, 2009;El-Bialy et al, 2009), recent reports showed no difference in the healing of the LIPUS treated and nontreated fractured bones (Emami et al, 1999;Rue et al, 2004;Handolin et al, 2005;Lubbert et al, 2008). The controversial reports about the clinical success of using LIPUS in repairing bone fractures could be due to the difference in the proximity of the fractured bone to the LIPUS transducer.…”

Section: Therapeutic Ultrasound and Its Role In Enhancing Tissue Engimentioning

confidence: 97%

“…While stem cells are stimulated by LIPUS in a dose dependent response (Schumann et al, 2006a); the optimum LIPUS treatment for skin fibroblasts is 10 minutes per day (Zhou et al, 2004). Moreover, clinical applications using LIPUS has been accepted to be 20 minutes per day for 3-4 weeks (Heckman et al, 1994;Cook et al, 1997;Kristiansen et al, 1997;Hadjiargyrou et al, 1998;Mayr et al, 2000;Warden et al, 2000;Nolte et al, 2001;Jingushi et al, 2007;Walker et al, 2007;Griffin et al, 2008;Busse et al, 2009), in-vitro responses vary from one day to 21 days. It is to be remembered that in-vitro experiments allow direct effect of LIPUS to the cells, while in-vivo application suffers from LIPUS power attenuation as explained above.…”

Section: Therapeutic Ultrasound and Its Role In Enhancing Tissue Engimentioning

confidence: 99%

Low Intensity Pulsed Ultrasound: A Laboratory and Clinical Promoter in Tissue Engineering Abstract

El‐Bialy¹

2010

Tissue Engineering

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This chapter will focus on the current and future applications of low intensity pulsed ultrasound (LIPUS) in tissue engineering at laboratory and clinical levels. Also, this chapter will explain the molecular basis of LIPUS stimulatory effects on cell expansion, differentiation and matrix production of different tissues. In addition, this chapter will provide information about the differences between LIPUS application in the laboratory settings and in the clinical applications with emphasis on tissue engineering applications. Moreover, this chapter will discuss why variability in outcome might occur when applying LIPUS in laboratory or clinical settings. Also, we will provide some tips on how to prevent potential inconsistency in treatment results with emphasis on the technique sensitivity and how a scientist or a clinician should be aware of this sensitivity of the application technique in order to optimize the utilization of LIPUS in different settings. This chapter will set a few hypotheses and potential new applications of utilizing LIPUS in other tissue engineering applications. The outcome of this chapter will be an understanding of the advantages and limitations of using LIPUS in tissue engineering applications either at the laboratory or in clinical settings.

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“…Rat coccygeal intervertebral disc tissues were also obtained as described previously. 9,10 The nucleus pulposus tissue was removed by cutting the annulus fibrosus transversely with a surgical knife under a dissecting microscope. The nucleus pulposus tissue was then digested in a mixture of 0.01% trypsin-EDTA solution (0.05% trypsin-EDTA, Gibco) for 30 min.…”

Section: Cell Isolation and Culturementioning

confidence: 99%

“…6 LIPUS has already been applied clinically to promote bone union in the treatment of fractures. [7][8][9] Iwashina and colleagues assessed the influence of LIPUS on rabbit intervertebral discs in vitro and found that it enhanced the ability of disc cells to proliferate and synthesize proteoglycans. 10 However, few studies have evaluated the influence of LIPUS on intervertebral discs and their constituent cells alone, and in particular cytokine pathways have received scant attention.…”

mentioning

confidence: 99%

Low‐intensity pulsed ultrasound stimulation enhances TIMP‐1 in nucleus pulposus cells and MCP‐1 in macrophages in the rat

Omi

Mochida

Iwashina

et al. 2008

Journal Orthopaedic Research

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Recent studies have reported that low-intensity pulsed ultrasound (LIPUS) stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells, and moreover promotes the secretion of MCP-1 (monocyte chemotaxis protein-1) from macrophages in a disc organ culture model. These findings suggest the possible application of LIPUS for biological repair of disc degeneration and herniation. Although the mechanisms involved are not well understood, several cytokine pathways may play a role. Therefore, in order to evaluate the effect of LIPUS stimulation on cytokine production by nucleus pulposus cells and macrophages, in vitro culture studies were designed. Nucleus pulposus cells and macrophages were collected from Sprague-Dawley rats, cultured separately in a monolayer, and stimulated with LIPUS for 7 days. After culture, the culture medium and the cells were analyzed by cytokine array, RT-PCR, and ELISA. Cytokine array showed that LIPUS stimulation significantly upregulated TIMP-1 (tissue inhibitor of metalloproteinase-1) in the nucleus pulposus and MCP-1 in macrophages in comparison with the control. This was confirmed at the gene level by RT-PCR in nucleus pulposus cells and macrophages after stimulation with LIPUS. Quantitative evaluation of these proteins by ELISA showed higher levels in nucleus pulposus cells and macrophages stimulated by LIPUS than in controls. These results showed that LIPUS stimulation significantly activated TIMP-1 and MCP-1 in nucleus pulposus cells and macrophages at both the protein and gene levels, suggesting that LIPUS may be a promising supplemental treatment for intervertebral disc herniation. ß

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Acceleration of Fresh Fracture Repair Using the Sonic Accelerated Fracture Healing System (SAFHS): A Review

Cited by 80 publications

References 29 publications

Effects of low intensity pulsed ultrasound stimulation on bone regeneration in rat parietal bone defect model

Effects of low intensity pulsed ultrasound stimulation on bone regeneration in rat parietal bone defect model

Low Intensity Pulsed Ultrasound: A Laboratory and Clinical Promoter in Tissue Engineering Abstract

Low‐intensity pulsed ultrasound stimulation enhances TIMP‐1 in nucleus pulposus cells and MCP‐1 in macrophages in the rat

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