Acceleration of Gastric Emptying and Improvement of GERD Outcome After Laparoscopic Sleeve Gastrectomy in Non-diabetic Obese Patients

Salman, Mohamed Abdalla; Mikhail, Hani Maurice Sabri; Abdelsalam, Ahmed; Abdallah, Ahmed; Elshafey, Hossam E; Abouelregal, Tarek Elsayed; Omar, M. M.; Elkassar, Hesham; Ahmed, Rasha; Atallah, Mohammad; Shaaban, Hossam El‐Din; Abdellatif, Zeinab; Elkholy, Shaimaa; Salman, Ahmed

doi:10.1007/s11695-020-04547-8

Cited by 18 publications

(11 citation statements)

References 29 publications

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“…Gastric emptying studies have been performed following VSG, however the results have been highly variable. VSG has been reported to have no effect on gastric emptying [ 44 ], or accelerate gastric emptying and were dependent upon the ingested gastric contents [ 25 , 45 , 46 ]. Results varied between liquids that showed both delayed and increased gastric emptying, semi-solid meals that showed unchanged or accelerated gastric emptying, or solid meals that also showed both delayed and accelerated gastric emptying [ 25 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…VSG has been reported to have no effect on gastric emptying [ 44 ], or accelerate gastric emptying and were dependent upon the ingested gastric contents [ 25 , 45 , 46 ]. Results varied between liquids that showed both delayed and increased gastric emptying, semi-solid meals that showed unchanged or accelerated gastric emptying, or solid meals that also showed both delayed and accelerated gastric emptying [ 25 , 45 , 46 ]. These studies typically utilized radionuclide scintigraphy and magnetic resonance imaging at a 3-month time point following VSG.…”

Section: Discussionmentioning

confidence: 99%

“…We also examined the calcium dynamics in ICC networks that are responsible for the generation of gastric pacemaker activity and the remodelling of ICC networks and genes that are preferentially expressed in cells that make up the SIP syncytium i.e., S mooth muscle cells, I CC and P DGFRα + cells, the cellular components responsible for excitability in the stomach [ 49 ]. We examined the changes over a 4-month time period as this time period is similar to that often used for the radionuclide scintigraphy and magnetic resonance imaging studies of gastric emptying [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, studies examining these changes are limited and controversial. Following VSG, accelerated gastric emptying has been reported using gastric scintigraphy [ 25 , 26 ], or magnetic resonance imaging [ 27 ]. Further, it has been shown, using electrical mapping, aberrant ectopic pacemaking and electrical quiescence leading to chronic dysmotility after VSG surgery [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

et al. 2022

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Obesity is a critical risk factor of several life-threatening diseases and the prevalence in adults has dramatically increased over the past ten years. In the USA the age-adjusted prevalence of obesity in adults was 42.4%, i.e., with a body mass index (BMI, weight (kg)/height (m)2) that exceeds 30 kg/m2. Obese individuals are at the higher risk of obesity-related diseases, co-morbid conditions, lower quality of life, and increased mortality more than those in the normal BMI range i.e., 18.5–24.9 kg/m2. Surgical treatment continues to be the most efficient and scientifically successful treatment for obese patients. Sleeve gastrectomy or vertical sleeve gastrectomy (VSG) is a relatively new gastric procedure to reduce body weight but is now the most popular bariatric operation. To date there have been few studies examining the changes in the cellular components and pacemaker activity that occur in the gastric wall following VSG and whether normal gastric activity recovers following VSG. In the present study we used a murine model to investigate the chronological changes of gastric excitability including electrophysiological, molecular and morphological changes in the gastric musculature following VSG. There is a significant disruption in specialized interstitial cells of Cajal in the gastric antrum following sleeve gastrectomy. This is associated with a loss of gastric pacemaker activity and post-junctional neuroeffector responses. Over a 4-month recovery period there was a gradual return in interstitial cells of Cajal networks, pacemaker activity and neural responses. These data describe for the first time the changes in gastric interstitial cells of Cajal networks, pacemaker activity and neuroeffector responses and the time-dependent recovery of ICC networks and normalization of motor activity and neural responses following VSG.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

et al. 2022

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“…Bariatric surgery has been an effective safe management for severe obesity. It is mainly based on restricting the gastric volume and/or inducing malabsorption with intestinal bypass [2]. However, inspired by the advances in digestive physiology knowledge regarding the satiety and hunger control, a novel bariatric procedure initiating neuroendocrinal alterations rather than just performing mechanical restriction and/or mal-absorption should be objected [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic Single Anastomosis Sleeve Ileal Bypass with Follow-up of Weight Loss and Metabolic Impact

Abdalaziz

Sarhan²,

Abou-Eisha³

et al. 2022

Open Access Maced J Med Sci

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Background: Bariatric surgery has been an effective safe management for severe obesity. The newly developed single-anastomosis sleeve ileal (SASI) bypass has shown efficacy as a functional as well as mechanical restrictive bariatric procedure, with a neuroendocrine modulation effect. SASI bypass is still an investigational procedure, hence, more evidence is needed till it is declared as a standard bariatric procedure by the IFSO. Aim of the study: The current work aimed to describe our experience regarding the technical steps, the efficacy and the short-term outcome of SASI bypass procedure in patients with severe obesity. Patients and methods: Forty seven patients with severe obesity underwent SASI bypass procedure. They were followed till 1 year postoperatively. The weight loss, comorbidities and laboratory changes were assessed. Results: Patients evaluation at the 1-year postoperative follow up revealed a mean %TWL of 37.55 ± 6.17 and a mean %EBWL of 76.21 ± 9.8. The remission rates of T2DM, hyperlipidemia and hypertension were 85.7%, 94.7% and 89.66%, respectively, with statistically high significant differences between the preoperative and 1-year postoperative comorbidities rate. Stepwise regression analysis demonstrated that only the preoperative HbA1C remained in the model predicting the %TWL, and the preoperative BMI was the remaining factor in the model predicting the %EBWL in the study patients. Conclusion: The present study adds a new evidence to the promising outcome of the newly introduced SASI bypass procedure. After one year, the study patients showed excellent weight loss and comorbidities remission together with acceptable major complication rates.

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Endoscopic Evaluation of De Novo Esophagitis and Barrett’s Esophagus, 5 Years After Sleeve Gastrectomy

et al. 2022

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Acceleration of Gastric Emptying and Improvement of GERD Outcome After Laparoscopic Sleeve Gastrectomy in Non-diabetic Obese Patients

Cited by 18 publications

References 29 publications

Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

Laparoscopic Single Anastomosis Sleeve Ileal Bypass with Follow-up of Weight Loss and Metabolic Impact

Endoscopic Evaluation of De Novo Esophagitis and Barrett’s Esophagus, 5 Years After Sleeve Gastrectomy

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