Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy

Dong, Bingqi; Liao, Zhi-Kai; Yue, Le; Jiang, Shan; Luo, Longfei; Miao, Fei; Poole, I. Caroline Le; Lei, Tiechi

doi:10.1016/j.mad.2023.111779

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…NB-UVB phototherapy acts as an efficient treatment modality to induce skin re-pigmentation in stable vitiligo. Although NB-UVB phototherapy was confirmed to be an efficient treatment option, the repigmentation responses to that PT differs significantly in various vitiligo cases and re-pigmentation might only appear after several months of treatment [13] . Thus, the combination of NBUVB and another treatment modality could be used in an effort to achieve faster and greater re-pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between the Efficacy of Trichloroacetic Acid 30% versus Intradermal 5 Fluorouracil Injection in Treatment of Vitiligo with or without Narrow Band Ultraviolet B Phototherapy

2023

The Egyptian Journal of Hospital Medicine

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Background: Vitiligo is a challenging disease, which significantly impaired quality of life (QoL). In recent years, there are numerous therapeutic modalities available that aim to stop progression with a subsequent induction of skin repigmentation. Combination among different modalities could improve the response, reduces the adverse events, and reduces the course required to achieve re-pigmentation in vitiligo. Objective: To compare the efficacy of trichloroacetic acid (TCA) chemical peel (30% concentration) versus intradermal injection of 5 Fluorouracil Injection (5-FU) both with and without Narrow Band Ultraviolet B (NB-UVB) Phototherapy (PT) in management of stable non-segmental vitiligo (NSV). Patients and Methods: This comparative prospective interventional study comprised 60 patients with stable NSV. Patients were divided into two equal groups: Group I and group II. Lesion 1 in both groups was treated with only TCA 30%, while, lesion 2 was treated with only intradermal injection of 5-FU. In group II, each lesion was followed by the application of NBUVB sessions twice/week. Results: Based on the Physician's Global Assessment (PGA) score, the present study demonstrated a highly statistically significant increase in the percentage of improvement among group II compared to group I. According to the PGA score, our study demonstrated a statistically significant increase in the percentage of improvement among the subgroup 5-FU II+ NBUVB compared to 5-FU I. Conclusion: It could be concluded that the combination therapies of each of TCA or 5-FU with NBUVB ranked higher than monotherapy with either TCA or 5-FU in inducing successful re-pigmentation in stable NSV patients.

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Section: Discussionmentioning

confidence: 99%

Comparative Study between the Efficacy of Trichloroacetic Acid 30% versus Intradermal 5 Fluorouracil Injection in Treatment of Vitiligo with or without Narrow Band Ultraviolet B Phototherapy

2023

The Egyptian Journal of Hospital Medicine

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“…In addition, melanocytes and fibroblasts present a senescence pattern in vitiligo skin ( 140 – 142 ). IFNγ and TNF-α were shown to induce senescence in melanocytes ( 143 , 144 ), and it would be interesting to evaluate the impact of type-2 cytokines in senescence in vitiligo given that IL-13 can promote senescence in submandibular glands ( 145 ). Nonetheless, type-2-related cytokines may also be protective in some subclinical subsets of vitiligo, since dupilumab induced or worsened vitiligo in AD patients ( 100 , 146 – 148 ).…”

Section: Vitiligomentioning

confidence: 99%

Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?

Migayron,

Bordes,

Closs

et al. 2024

Front. Immunol.

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Chronic inflammatory skin diseases are multifactorial diseases that combine genetic predisposition, environmental triggers, and metabolic disturbances associated with abnormal immune responses. From an immunological perspective, the better understanding of their physiopathology has demonstrated a large complex network of immune cell subsets and related cytokines that interact with both epidermal and dermal cells. For example, in type-1-associated diseases such as alopecia areata, vitiligo, and localized scleroderma, recent evidence suggests the presence of a type-2 inflammation that is well known in atopic dermatitis. Whether this type-2 immune response has a protective or detrimental impact on the development and chronicity of these diseases remains to be fully elucidated, highlighting the need to better understand its involvement for the management of patients. This mini-review explores recent insights regarding the potential role of type-2-related immunity in alopecia areata, vitiligo, and localized scleroderma.

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“…The MMP9 inhibitor GM6001 has been shown to decrease the production of the soluble form of the receptor KIT by suppressing ectodomain shedding 194 . Since MMP9's proteolytic activity is also involved generating soluble KITLG, 166 this raises the question of whether administering the MMP9 inhibitor GM6001 could be used to block the formation of soluble KITLG, thereby increasing the amount of membrane‐bound KITLG and providing potential hair and skin pigmentation‐stimulatory effects.…”

Section: Potential Therapeutic Targets/agentsmentioning

confidence: 99%

Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases

Sevilla,

Grichnik

2024

Experimental Dermatology

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KIT ligand and its associated receptor KIT serve as a master regulatory system for both melanocytes and mast cells controlling survival, migration, proliferation and activation. Blockade of this pathway results in cell depletion, while overactivation leads to mastocytosis or melanoma. Expression defects are associated with pigmentary and mast cell disorders. KIT ligand regulation is complex but efficient targeting of this system would be of significant benefit to those suffering from melanocytic or mast cell disorders. Herein, we review the known associations of this pathway with cutaneous diseases and the regulators of this system both in skin and in the more well‐studied germ cell system. Exogenous agents modulating this pathway will also be presented. Ultimately, we will review potential therapeutic opportunities to help our patients with melanocytic and mast cell disease processes potentially including vitiligo, hair greying, melasma, urticaria, mastocytosis and melanoma.

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Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy

Cited by 4 publications

References 24 publications

Comparative Study between the Efficacy of Trichloroacetic Acid 30% versus Intradermal 5 Fluorouracil Injection in Treatment of Vitiligo with or without Narrow Band Ultraviolet B Phototherapy

Comparative Study between the Efficacy of Trichloroacetic Acid 30% versus Intradermal 5 Fluorouracil Injection in Treatment of Vitiligo with or without Narrow Band Ultraviolet B Phototherapy

Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?

Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases

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