Acceleration of the genetic gain for nutraceutical improvement of adlay (
            <i>Coix</i>
            L.) through genomic approaches: current status and future prospects

Huda, Nurul; Li, Xiangdong; Jahan, Tanzim; He, Yuqi; Guan, Chaonan; Zhang, Kaixuan; Gao, Ainong; Georgiev, Milen I.; Zhou, Meiliang

doi:10.1080/87559129.2022.2067175

Cited by 6 publications

(3 citation statements)

References 105 publications

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“…Coix seed is a homologous drug food in China that has anticancer and antioxidant functions, reduces blood lipids and blood sugar, and supports immunological modulation [6][7][8]. Coix seed extract's physiological actions are ascribed to several phytochemical components, such as amino acids, vitamins, phenolics, and polysaccharides [9]. Polysaccharides are structural substances and energy sources of plant cells.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiaging Activity of Fermented Coix Seed Polysaccharides on Caenorhabditis elegans

Zhao

Yan

et al. 2023

Nutrients

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Aging is closely related to many diseases and is a long-term challenge that humans face. The oxidative damage caused by the imbalance of free radicals is an important factor in aging. In this study, we investigate the antioxidant and antiaging activities of fermented coix seed polysaccharides (FCSPs) via in vitro and in vivo experiments. The FCSPs were extracted by fermenting coix seed with Saccharomyces cerevisiae for 48 h and utilizing water-extracted coix seed polysaccharides (WCSPs) as a control. Their antiaging activity and mechanism were evaluated based on the antiaging model organism Caenorhabditis elegans (C. elegans). The results showed that the molecular weight of the FCSPs extracted by fermentation was smaller than that of the WCSPs, making them more easily absorbed and utilized. At a concentration of 5 g/L, the FCSPs’ capacity to scavenge the DPPH·, ABTS+·, OH·, and O2−· radicals was greater than the WCSPs’ capacity by 10.09%, 14.40%, 49.93%, and 12.86%, respectively. Moreover, C. elegans treated with FCSPs exhibited higher antioxidant enzyme activities and a lower accumulation of malonaldehyde. By inhibiting the expression of the pro-aging genes daf-2 and age-1, and upregulating the expression of the antiaging genes daf-16, sod-3, skn-1, and gcs-1 in the insulin/insulin-like growth factor-1 (IIS) signaling pathway, the FCSPs could effectively enhance stress tolerance and delay C. elegans aging. The lifespan of C. elegans in the FCSPs group was 5.91% higher than that of the WCSPs group. In conclusion, FCSPs exert better antioxidant and antiaging effects than WCSPs, which can act as a potential functional ingredient or supplement in food.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiaging Activity of Fermented Coix Seed Polysaccharides on Caenorhabditis elegans

Zhao

Yan

et al. 2023

Nutrients

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“…are classified as the top grade in ‘Shennong Materia Medica Classic’, which can be used to make porridge, rice, alcoholic beverages and various pastas for people to eat (Li et al ., 2024). As a nutritious natural food, coix seed is rich in protein, sterols, amino acids and polysaccharides (Huda et al ., 2023). Numerous pharmacological studies have reported that coix seed has various biological and pharmacological activities, including anti‐inflammatory (Huda et al ., 2023), regulating blood lipids (Zheng et al ., 2022), antioxidant (Chen et al ., 2020), immunomodulatory (Wang et al ., 2022a) and anti‐cancer (Igbokwe et al ., 2024).…”

Section: Introductionmentioning

confidence: 99%

“…As a nutritious natural food, coix seed is rich in protein, sterols, amino acids and polysaccharides (Huda et al ., 2023). Numerous pharmacological studies have reported that coix seed has various biological and pharmacological activities, including anti‐inflammatory (Huda et al ., 2023), regulating blood lipids (Zheng et al ., 2022), antioxidant (Chen et al ., 2020), immunomodulatory (Wang et al ., 2022a) and anti‐cancer (Igbokwe et al ., 2024). Unfortunately, a large number of analytical studies have discovered coix seed to be one of the most heavily polluted functional foods in Chinese markets due to mycotoxins (Kong et al ., 2013; Han et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

UV light treatment (278 nm) for detoxification of aflatoxins and application in edible and medicinal herb coix seed

Zou,

Sun,

et al. 2024

Int J of Food Sci Tech

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SummaryAflatoxins (AFs) are highly toxic and cancer‐causing compounds, which could be commonly found in agricultural products and feeds. However, different tactics for detoxification have significant limitations due to their unsuitability for use. In this study, an LED UV curing system (wavelength: 278 nm, irradiation energy: 100%, irradiation time: 10 min) could effectively reduce pure aflatoxin B1 (AFB1), pure aflatoxin B2 (AFB2) and pure aflatoxin G1 (AFG1) (detoxification rates are more than 80%). In addition, in vitro biocompatibility tests indicate that the hypertoxicity of the obtained AFs‐degraded solutions was significantly reduced, which might be because the unsaturated ketone structure in AFB1, AFB2 and AFG1 was broken. Moreover, in processed coix seed and dried boat‐fruited Sterculia seed samples, the amount of AF was greatly reduced, and the rate of degradation was more than 85% with irradiation for 30 min. These data adequately implied that the current work might offer a practical way to detoxify AFs in various medicinal plants and foods.

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Identification of anti-hyperuricemic components from Coix seed

Sui¹,

De-ping²,

Sun³

2023

Food Bioscience

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Acceleration of the genetic gain for nutraceutical improvement of adlay ( Coix L.) through genomic approaches: current status and future prospects

Cited by 6 publications

References 105 publications

Antioxidant and Antiaging Activity of Fermented Coix Seed Polysaccharides on Caenorhabditis elegans

Antioxidant and Antiaging Activity of Fermented Coix Seed Polysaccharides on Caenorhabditis elegans

UV light treatment (278 nm) for detoxification of aflatoxins and application in edible and medicinal herb coix seed

Identification of anti-hyperuricemic components from Coix seed

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