Accelerator Neutron Irradiation Facility for Hospital-Based Neutron Capture Therapy

Wang, C-K. C.; Eggers, P. E.; Crawford, H. L.

doi:10.1007/978-1-4615-2978-1_24

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…For practical treatments the proton beam current was estimated to be 4 to 50 mA. 2,3 Such currents will cause a significant challenge to the target cooling system, because lithium has a low melting point ͑181°C͒ and low thermal conductivity ͑85 W/m°C͒. If molten lithium is considered as the target, a target container with very thin wall thickness and high heat conductivity, high strength must be used.…”

Section: Introductionmentioning

confidence: 99%

Study of boron neutron capture therapy used neutron source with protons bombarding a thick 9Be target

1997

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Neutron sources created by 4-, 3.5-, and 3-MeV protons striking a thick beryllium target were studied via the time-of-flight technique. Protons were accelerated by the Peking University 4.5 MV electrostatic accelerator. Two disk-shaped 9Be targets with thickness 1.5 and 3 mm were used in the measurements. The time-of-flight spectra were observed at zero degrees with respect to the incident proton beam. The analysis to these time-of-flight spectra is given. The time-of-flight spectra were converted to the energy spectra and compared to a neutron spectrum of 7Li(p, n)7 Be reaction with incident energy 2.5 MeV, which was also measured in this work. Restricted by the spectrometer itself, the threshold of the measurements is 400 keV. The results show that by using several MeV protons bombarding a thick beryllium target, reactions other than 9Be(p, n)9B produce significant contributions to the neutron yield with energy less than 1 MeV.

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Section: Introductionmentioning

confidence: 99%

Study of boron neutron capture therapy used neutron source with protons bombarding a thick 9Be target

1997

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“…Previous designs for accelerator driven BNCT (Boron Neutron Capture Therapy) systems based on neutrons generated by @, n) reactions of low energy (few MeV) proton beams on lithium targets have required cw beam currents in the range of 20 to 50 milliamps (1,2). Achieving such high current levels will require substantial technical development, and will tend to be expensivea significant factor in determiwig whether such systems will be practical for widespread use in hospitals.…”

Section: Introductionmentioning

confidence: 99%

New concepts for compact accelerator/target for Boron Neutron Capture Therapy

Powell¹,

Ludewig²,

Todosow³

et al. 1997

AIP Conference Proceedings

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Two new target concepts, NIFTI and DISCOS, that enable a large reduction in the proton beam current n e e d @ o &~~ epithermal neutrons for BNCT (Boron Neutron Capture Therapy) are described. In the NIFTI concept, high ener& neutrons produced by @, n) reactions of 2.5 MeV protons on Li are down scattered to treatment energies (-20 keV) by relatively thin layers of PbF, and iron. In the DISCOS concept, treatment energy neutrons are produced directly in a succession of thin (-1 micron) liquid Li films on rotating Be foils. These foils interact with a proton beam that operates just above threshold for the @, n) reaction, with an applied DC field to re-accelerate the proton beam between the target foils.

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“…Hence it seems difficult to use over 20 mA of beam current. For higher power beam a rotating target [4] or Liz0 at the cost of lower neutron yield cou Id be used. …”

Section: Target Designmentioning

confidence: 99%

“…A beam energy of 2.5 MeV along with Li target appears to be the best choice in the aspect of neutronics [4]. And we consider that the use of Be target with a higher beam energy of 3.5 MeV is worthy of pursuing as it allows a simpler target system, which fits better into the hospital environment.…”

Section: Introdljctionmentioning

confidence: 97%

Design study of a linear accelerator system for neutron capture therapy

Kim

Chai²

Proceedings of the 1997 Particle Accelerator Conference (Cat. No.97CH36167)

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Freauencv AbstractA proton linear accelerator has been conceived to be used for Boron Neutron Capture Therapy (BNCT) and Neutron Radiography (NR) at the Korea Cancer Center Hospital in Seoul, Korea. The main accelerator is an RFQ which will accelerate protons from 90 keV to 3.5 MeV with a current of 50 mA in the present design. According to the PARMTEQ calculation, transm.ission efficiency is over 96 % for that current. Beam dynamics and rf properties of the RFQ have been studied along with beam transport and target systems. At present possibility of obtaining funding appears to be low, but we thought it is worthwhile to carry out the design study for the future proposal. MHz INTRODlJCTIONThe Korea Cancer Center Hospital (KCCH) in Seoul has used a MC50 cyclotron (Scandlitronics) for neutron therapy since 1986 [l]. To extentd the hospital's capability for cancer treatment, an accelerator system for BNCT has been proposed. A high current proton beam produces neutrons from the nuclear reactions such as 7Li(p,n)7Be or 'Be(p,n)'B, and then the neutron beam is moderated to epithermal energy (1 eV -10 keV). The reaction process for treatment is l ' B ( n ,~)~L i utilizing a high capture cross section of 'OB for thermal neutrons. The resulting reaction products produce the localized dose on the highly malignant cells [2].Regarding to accelerators for high current proton acceleration, RFQ and RFD seem promising among others. We first chose to study on RFQ siince the average current of near 80 mA has been already achieved by the Chalk River RFQ (to 600 keV) [3].The proton beam energy needed for BNCT is related to the choice of target. A beam energy of 2.5 MeV along with Li target appears to be the best choice in the aspect of neutronics [4]. And we consider that the use of Be target with a higher beam energy of 3.5 MeV is worthy of pursuing as it allows a simpler target system, which fits better into the hospital environment. We chose the current of 50 mA in the present design, which will produce the epithermal neutron flux of 5 x 109/cm2/sec with 7Li target at 2.5MeV.An RFQ to accelerate high current proton beam is highly demanding on diverse applications. As a result, designs of such RFQ accelerators are described by many authors [SI [6]. Our study here aims at oblaining our own design parameters. Besides the RFQ, the beam transport and the target systems have been studied, and some results are given 645 kV Length 4.9 m (3.8 m)in this report. DESIGN STUDY OF AN RFQ ACCELERATORThe accelerator system is composed of ion source, RFQ, low-energy and high-energy beam transport lines. A schematic view of the system is shown in Figure 1. The present design energy is 3.5 MeV with an intermediate goal of achieving 2.5 MeV. Design parameters are obtained using the PARMTEQ code [7] for both energies, and listed in Table 1. The cell parameters of the RFQ is shown in Figure 2 as a function of the longitudinal position. Figure 1: A schematic view of a linear accelerator system for BNCT The transmission efficiency is over 96 % for 50 m...

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Accelerator Neutron Irradiation Facility for Hospital-Based Neutron Capture Therapy

Cited by 7 publications

References 6 publications

Study of boron neutron capture therapy used neutron source with protons bombarding a thick 9Be target

Study of boron neutron capture therapy used neutron source with protons bombarding a thick 9Be target

New concepts for compact accelerator/target for Boron Neutron Capture Therapy

Design study of a linear accelerator system for neutron capture therapy

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