Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS

Baldanzi, Gabriel; Sayols-Baixeras, Sergi; Ekblom-Bak, Elin; Ekblom, Örjan; Dekkers, Koen F.; Hammar, Ulf; Nguyen, Diem; Ahmad, Shafqat; Ericson, Ulrika; Arvidsson, Daniel; Börjesson, Mats; Johanson, Peter J.; Smith, J. Gustav; Bergström, Göran; Lind, Lars; Engström, Gunnar; Ärnlöv, Johan; Kennedy, Beatrice; Orho-Melander, Marju; Fall, Tove

doi:10.1016/j.ebiom.2024.104989

Cited by 7 publications

References 76 publications

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Insomnia, OSA, and Mood Disorders: The Gut Connection

Pacheco,

Cedernaes,

Benedict

2024

Curr Psychiatry Rep

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Purpose of Review With the growing body of research examining the link between sleep disorders, including insomnia and obstructive sleep apnea (OSA), and the gut microbiome, this review seeks to offer a thorough overview of the most significant findings in this emerging field. Recent Findings Current evidence suggests a complex association between imbalances in the gut microbiome, insomnia, and OSA, with potential reciprocal interactions that may influence each other. Notably, specific gut microbiome species, whether over- or under-abundant, have been associated with variation in both sleep and mood in patients diagnosed with, e.g., major depressive disorder or bipolar disorder. Summary Further studies are needed to explore the potential of targeting the gut microbiome as a therapeutic approach for insomnia and its possible effects on mood. The variability in current scientific literature highlights the importance of establishing standardized research methodologies.

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Insomnia, OSA, and Mood Disorders: The Gut Connection

Pacheco,

Cedernaes,

Benedict

2024

Curr Psychiatry Rep

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Targeting Cognitive Resilience through Prebiotics: A Focused Perspective

Dalile,

Boyle,

Ruiz

et al. 2025

Advances in Nutrition

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Atypical gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice

Martin,

Bonneau,

Orfila

et al. 2024

Preprint

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Background. The gut bacterial ecosystem plays a key role in the host's energy metabolism, and potentially in the host's exercise capacity, recognized as a powerful predictor of health status and risk of mortality. Objective. To deepen our understanding of the gut bacterial ecosystem relationship with host's exercise capacity and energy metabolism, we characterized the gut microbiota in a cohort of healthy humans with heterogeneous exercise capacities, and next determined the impact of fecal microbiota transplantation (FMT) from donors of this cohort on energy metabolism and exercise capacity of recipient mice. Design. 50 male normo-weight participants (from inactive to elite endurance athletes) performed food frequency questionnaire (FFQ) and exercise tests to determine exercise capacity parameters (VO2max, fat oxidation, exercise energy expenditure). Metagenomic shotgun and metabolomic analyses were performed to characterize gut microbiota ecosystem and short-chain fatty acids (SCFAs) on human and mice fecal samples. Mice performed running exercise capacity tests and metabolic parameters were determined in skeletal muscle and plasma samples. Results. While our data support that the bacterial ecosystem appears to be modestly altered between individuals with low to high exercise capacities, we report that gut bacterial alpha-diversity, density, and functional richness are significantly reduced in athletes with very high exercise capacity. By using FMT, we report that the engraftment of these atypical gut microbiota improves insulin sensitivity and muscle glycogen stores into transfected mice. Conclusion. Our data highlight promising therapeutic perspectives in fecal transplantation from human donors selected based on exercise capacity parameters.

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Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS

Cited by 7 publications

References 76 publications

Insomnia, OSA, and Mood Disorders: The Gut Connection

Insomnia, OSA, and Mood Disorders: The Gut Connection

Targeting Cognitive Resilience through Prebiotics: A Focused Perspective

Atypical gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice

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