Accelerometer measured physical activity and sedentary time in individuals with multiple sclerosis versus age matched controls: A systematic review and meta-analysis

Macdonald, Eilidh; Buchan, Duncan S.; Cerexhe, Luke; Renfrew, Linda Miller; Sculthorpe, Nicholas

doi:10.1016/j.msard.2022.104462

Cited by 12 publications

(7 citation statements)

References 68 publications

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“…Indeed, only 25 % of participants achieved the US Department of Health and Human Services’ recommended 500 weekly MET-minutes of MVPA (ACSM, 2019, US Department of Health and Human Services, 2018 ), and just 18 % achieved V̇O 2peak at or above the American College of Sports Medicine (ACSM)’s 50th percentile for age and sex ( American College of Sports Medicine, 2022 ). These data align with recent meta-analyses that show significantly lower levels of both cardiorespiratory fitness and physical activity in persons with MS compared to matched controls ( Langeskov-Christensen et al, 2015 , Macdonald et al, 2023 ). While there was a low proportion of both active and fit individuals enrolled in this study, there was likewise a low prevalence of cognitive impairment.…”

Section: Discussionsupporting

confidence: 91%

Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis

Snow,

Landine,

Chaves

et al. 2023

IBRO Neuroscience Reports

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Section: Discussionsupporting

confidence: 91%

Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis

Snow,

Landine,

Chaves

et al. 2023

IBRO Neuroscience Reports

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“…Persons with MS engaged in substantially less PA than healthy controls (P < .05), and this is consistent with previous research. 6,33 Notably, we extended current knowledge by using steps-based metrics to quantify natural effort and further illustrated a full range of intensity levels participated by persons with MS. Herein, the MS sample had a mean Peak-30 CAD of 53.3 steps/minutes and Peak-1 CAD of 83.8 steps/minutes, and these were lower than healthy controls (72.9 and 102.0 steps/minutes, respectively), the U.S. general population (71.6 and 100.7 steps/minutes, respectively) 11 and some older adult samples (eg, 61.7 and 100.8 steps/minutes in older cancer survivors). [34][35][36] This suggests a deleterious impact of MS on daily ambulatory behavior, including total volume, intensity and persistence, and physical capacity for higher-intensity PA.…”

Section: Discussionmentioning

confidence: 95%

“…8,37 Furthermore, our findings revealed patterns of light-intensity PA (<100 steps/ minutes) in MS distinct from previous studies. 33 One recent meta-analysis summarized accelerometry outcomes in MS and suggested overall more sedentary time and less light intensity PA (reported as minutes/day or percent monitor time) compared with healthy controls (effect size of 0.29 and −0.34, respectively). 33 However, we reported that the MS sample spent less time in some light-intensity levels (40-99 steps/minutes), but accumulated more incidental movement (1-19 steps/minutes) and comparable non-movement (zero cadence) and sporadic movement (20-39 steps/ minutes) as healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…33 One recent meta-analysis summarized accelerometry outcomes in MS and suggested overall more sedentary time and less light intensity PA (reported as minutes/day or percent monitor time) compared with healthy controls (effect size of 0.29 and −0.34, respectively). 33 However, we reported that the MS sample spent less time in some light-intensity levels (40-99 steps/minutes), but accumulated more incidental movement (1-19 steps/minutes) and comparable non-movement (zero cadence) and sporadic movement (20-39 steps/ minutes) as healthy controls. Future research might examine peak cadence in diverse MS samples and identify clinically relevant thresholds associated with specific health benefits.…”

Section: Discussionmentioning

confidence: 99%

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Free-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking?

Zheng,

Jeng,

Huynh

et al. 2023

Neurorehabil Neural Repair

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Background Physical function and walking performance have become important outcomes in clinical trials and rehabilitation involving persons with multiple sclerosis (MS). However, assessments conducted in controlled settings may not reflect real-world capacity and movement in a natural environment. Peak cadence via accelerometry might represent a novel measure of walking intensity and prolonged natural effort under free-living conditions. Objective We compared peak 30-minute cadence, peak 1-minute cadence, and time spent in incremental cadence bands between persons with MS and healthy controls, and examined the associations between peak cadence and laboratory-assessed physical function and walking performance. Methods Participants (147 MS and 54 healthy controls) completed questionnaires on disability status and self-reported physical activity, underwent the Short Physical Performance Battery, Timed 25-Foot Walk, Timed Up and Go, and 6-Minute Walk, and wore an accelerometer for 7 days. We performed independent samples t-tests and Spearman bivariate and partial correlations adjusting for daily steps. Results The MS sample demonstrated lower physical function and walking performance scores, daily steps, and peak cadence ( P < .001), and spent less time in purposeful steps and slow-to-brisk walking (40-119 steps/minutes), but accumulated more incidental movement (1-19 steps/minutes) than healthy controls. The associations between peak cadence and performance outcomes were strong in MS (| rs| = 0.59-0.68) and remained significant after controlling for daily steps (| prs| = 0.22-0.44), P-values < .01. Peak cadence was inversely correlated with age and disability, regardless of daily steps ( P < .01). Conclusions Our findings provide preliminary evidence for the potential use of peak cadence with step-based metrics for comprehensively evaluating free-living walking performance in MS.

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“…Persons with MS (PwMS) manifest with heterogenous symptoms, commonly including spasticity, paralysis, walking di culties, fatigue and cognitive decline [2]. These primary disease symptoms often limit PwMS to engage in physical activity (PA) [3], making them more sedentary and less active compared to healthy controls (HC) [4]. To date, a plethora of evidence shows the bene cial effects of structured exercise on MS symptoms, cardiorespiratory tness and the risk of developing comorbidities that are associated with disability and disease progression, such as obesity and hypertension [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The effect of structured exercise on non-exercise physical activity and sedentary behaviour in persons with mild Multiple Sclerosis and healthy controls

Nieste

Spaas

Franssen

et al. 2023

Preprint

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Background Exercise interventions fail to increase objective physical activity (PA) in persons with Multiple Sclerosis (PwMS), while they self-report higher exercise participation. This suggests that PwMS change their non-exercise PA (NEPA). We aimed to explore NEPA changes of PwMS and healthy controls (HC), and whether these constrain exercise adaptations. Methods Twenty-nine mildly-disabled PwMS and 26 HC completed a 10-month home-based running program. The primary outcome was time in different NEPA intensities (light intensity PA [LIPA] and moderate-to-vigorous intensity PA [MVPA]) and in sedentary behaviour ([SB]; total and uninterrupted SB) at baseline (T1), after 5 (T2) and 10 (T3) months of exercise. Data were averaged over days with and without exercise sessions (EX and NONEX days). Secondary outcomes included patient-reported and physical exercise adaptations (fatigue, walking mobility, blood pressure, body composition and cardiorespiratory fitness). Results A significant reduction in non-exercise MVPA was observed from T1 to T2 (-113±31 min/week, p=0.006) and from T1 to T3 (-95±26 min/week, p=0.007) in PwMS, which approximately matched the weekly exercise duration at those time points. PwMS also increased their uninterrupted SB on NONEX days compared to EX days (+0.7±0.3h, p=0.003). There were no changes in MVPA or SB of HC (group×time effect MVPA: p=0.017; group×EX day effect uninterrupted SB: p=0.003). Secondary outcomes improved similarly in both groups and were not associated with NEPA/SB changes. Conclusions In contrast to HC, PwMS significantly changed their NEPA and the pattern in which they accumulated SB in response to structured exercise. This might be a necessary behavioural compensation in order to adhere to the exercise intervention and did not constrain patient-reported and physical outcomes. Future research is warranted to unravel the underlying causes and to investigate the effects on other exercise adaptations, such as cardiometabolic health. Trial registration The present study was registered (December 10, 2019) at clinicaltrials.gov as NCT04191772.

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Accelerometer measured physical activity and sedentary time in individuals with multiple sclerosis versus age matched controls: A systematic review and meta-analysis

Cited by 12 publications

References 68 publications

Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis

Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis

Free-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking?

The effect of structured exercise on non-exercise physical activity and sedentary behaviour in persons with mild Multiple Sclerosis and healthy controls

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