Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial

Abstract

This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF 4 ) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children's acceptability. Sixty children (6-8 y/o) were randomly divided into TiF 4 (2.45% F -), NaF (2.26% F -) or placebo (control) groups. Varnishes were applied on permanent teeth once a week for the first 4 weeks and after the 6 th and 12 th months of the study. The variables were as follows: International Caries Detection and Assessment System (ICDAS) scores, quantitative fluorescence changes, visual plaque index (VPI) and degree of acceptability. Two-way RM-ANOVA, ANOVA/Tukey and χ2 tests were performed (p < 0.05). No differences were found between the treatments with respect to ICDAS scores (p = 0.32). Only TiF 4 reduced the mean fluorescence loss significantly at 18 months compared to the baseline (p = 0.003). TiF 4 showed a lower percentage of new caries lesions by tooth surface than the placebo, while NaF did not induce such a change (p < 0.014). Regardless of the treatment, more than 95% of the participants reported being satisfied. For all groups, the VPI decreased significantly at 3 months compared to the baseline value (p < 0.001), with no differences between the treatments (p = 0.17). TiF 4 had a similar ability to control caries lesions as NaF; however, only TiF 4 differed from the placebo (p = 0.004). The acceptability of TiF 4 varnish was similar to that of NaF varnish.

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis

“…In 42 studies, 35.7% orthodontics WSLs, 4.8% non-orthodontics WSLs, 16.7% WSLs without special introductions, 7.1% ACLs,19.0% ECLs, 2.4% molar incisor hypo-mineralization (MIH) [ 75 ] and 14.3% artificial lesions compose all lesions. But a single ACL study with a description of ICDAS = 2 resulted in its inclusion in NMA [ 68 ]. Due to the uncertainty of using fluoride toothpaste in oral education (Some articles have explicit descriptions, others do not), we did not consider the efficacy of fluoride toothpaste in this study.…”

Professionally applied fluorides for preventing and arresting dental caries in low‐ and middle‐income countries: Systematic review

“…Various forms of fluoride, including NaF gel, NaF-HF gel, APF gel, APF foam, Na FV, titanium tetra FV, and SDF, were utilized in these studies. Among the 13 studies, 7 reported a significant reduction in new caries development on permanent teeth with the use of professionally applied fluorides compared with a placebo or no treatment (p < 0.05) [31][32][33][46][47][48][49]. However, the remaining six studies did not find a statistically significant difference (p > 0.05) [50,51].…”