Acceptability and Long‐Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers: I. Acceptability of Drug Treatment

Tatemichi, Masayuki; Hamaguchi, Tsutahiro; Hashira, Munetaka; Hayashi, Takeshi; Ito, Masato; Nakatani, Atsushi; Hiro, Hisanori; Mori, Koji; Ookubo, Yasushi; Ezaki, Takafumi; Sugimori, Hiroki; Yoshida, Katsumi

doi:10.1539/joh.44.166

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Furthermore, even when occupational health practitioners do provide advice to employees with hyperlipidemia, those employees are not inclined to receive such treatment. Tatemichi et al reported that when health experts advised employees at large workplaces who were found to require treatment for hypercholesterolemia to start drug therapy following a lack of response to three-month dietary therapy, approximately 50% agreed to receive drug therapy, while one-third of those who did not agree to receive drug therapy also rejected dietary therapy [19]. This was likely because employees with hypercholesterolemia have fewer subjective symptoms than those with other diseases and are unlikely to exhibit presenteeism despite poorly controlled cholesterol levels [20].…”

Section: Discussionmentioning

confidence: 99%

Occupational Health Services Improve Effective Coverage for Hypertension and Diabetes Mellitus at Japanese Companies

Hashiguchi

Nagata

Mori

et al. 2019

J UOEH

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The World Health Organization (WHO) aims to enable all people to receive health services, and has proposed effective coverage (EC) as an index for this aim. EC refers to "the fraction of potential health gain that is actually delivered to the population through the health system, given its capacity," and is used to indicate the percentage of the population whose diseases are well controlled among those who require treatment or are receiving treatment. This study aimed to evaluate the effects of occupational health services on EC. We hypothesized that occupational health services provided to employees by full-time occupational health practitioners, such as occupational physicians and occupational health nurses, improve EC for hypertension, diabetes mellitus and hyperlipidemia compared to those services provided by part-time occupational health practitioners. We conducted a cross-sectional study to analyze the results of general medical examinations, personnel information, and medical expense claims in fiscal year 2011. A total of 91,351 male employees at a company group participated in the study. The EC for hypertension, diabetes mellitus and hyperlipidemia was measured and compared between the employees in workplaces with occupational health practitioners (OH group) and the employees in workplaces without occupational health practitioners (non-OH group). The EC for hypertension and diabetes mellitus was significantly greater in the OH group than in the non-OH group (aOR: 1.41, 95% CI: 1.20 -1.66 for hypertension; aOR: 1.53, 95% CI: 1.17 -2.00 for diabetes mellitus), while the EC for hyperlipidemia was comparable (aOR: 1.11, 95% CI: 0.92 -1.34). Occupational health services provided by full-time occupational health practitioners greatly improve health management after a medical examination.

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Section: Discussionmentioning

confidence: 99%

Occupational Health Services Improve Effective Coverage for Hypertension and Diabetes Mellitus at Japanese Companies

Hashiguchi

Nagata

Mori

et al. 2019

J UOEH

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“…In this study, the 671 subjects included 656 who accepted drug treatment (DT group) in part I of this study [10], and 15 who had taken cholesterol-lowering drugs before this study and were not included in part I. Out of 671 subjects, 31 subjects were excluded because 25 had no follow-up data (rejected participation in this part II study), and 6 had no information about compliance.…”

Section: Compliance With Drug Treatmentmentioning

confidence: 99%

“…We therefore conducted a prospective study. The profiles of participants were described in detail in part I of this study 10). Briefly, we recommended a treatment with simvastatin, an HMG-CoA reductase inhibitor, in addition to a diet-based treatment program, for all eligible workers, with hypercholesterolemia diagnosed in a legally required medical check-up, and who had not been improved after a 3-month diet therapy.…”

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confidence: 99%

Acceptability and Long‐Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers

Tatemichi

Hamaguchi

Hashira

et al. 2002

Journal of Occupational Health

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Acceptability and Long-Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers: II. Long-Term Compliance with Drug Treatment: Masayuki TATEMICHI, et at. undertook a prospective study to assess the long-term compliance of Japanese male workers with drug treatment for hypercholesterolemia. In workers who accepted treatment with simvastatin, an HMG-CoA reductase inhibitor, compliance was monitored every 6 months with an interview. Factors affecting compliance were identified by using the background characteristics of subjects and a self-administered questionnaire on their type of job, job style, private lifestyle and psychological status at work. Mean (SD) follow-up periods were 21.5 (10.6) months for 640 workers, and 240 noncompliant « 75 % of prescription) subjects were found. Of these 240, 23 (9.6%) were restored to be finally compliant at the last follow-up (re-compliant). We assessed the time-course rate of compliant subjects and factors affecting drug compliance using Cox proportional hazard model by setting occurrence of a noncompliant attitude to an endpoint. The cumulative compliance rate at 36 months was 0.508 when excluding 23 re-compliant subjects and 0.529 when considering them as compliant. Multivariate analysis showed that age and present medical illness with hypertension (HT) in background characteristics of subjects and the habit of having breakfast daily in factors related to private-lifestylewere significantly associated with compliance. Baseline lipid profiles and work related issues were not associated with compliance. The occurrence rate of side effects did was similar in compliant and noncompliant workers. In this study, even though considering the re-compliant subjects, the rate of compliant subjects over a 3-yr period was considerably low (around 50%). The factors related to compliance were age, present illness with HT and the habit of having breakfast daily. (J Occup Health 2002; 44: 307-314)

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“…Yamaoka et al evaluated adherence to a α-glucosidase inhibitor on a four-grade scale ("take all as instructed," "usually take," "sometimes take," and "don't take") and demonstrated that adherence was lower than with other oral antidiabetic agents [24]. Tatemichi et al demonstrated that adherence improved according to the instructtions given by physician in an evaluation of long-term adherence in male Japanese workers using a four-grade scale (always took the drug according to the prescription (complete), occasionally forgot to take the drug (good), frequently forgot to take the drug (poor), always forgot to take the drug (very poor)) [25]. Evaluating adherence on a four-grade scale for forgetting to take medication or having left-over medication ("happens a lot," "sometimes happens," "doesn't happen very often," "almost never happens"), Kamei et al identified occupation and having diabetes as factors affecting adherence [26].…”

Section: Introductionmentioning

confidence: 99%

Factors Related to Medication Adherence of Cognitively Impaired Patients in Community Pharmacies

Nanaumi¹,

Onda²,

Mukai³

et al. 2012

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Objective: The objective of the study was to identify factors related to donepezil medication adherence ("adherence") of cognitively impaired patients in community pharmacies. Methods: One hundred and twenty community pharmacies in 28 regions in Japan were randomly selected. Questionnaires were mailed to these pharmacies. The pharmacists answered based on the medication profiles ("YAKUREKI") of the patients given donepezil at their pharmacies. The survey items were "adherence", "who is the key person" and ‘the key person’s understanding and awareness of donepazil and its symptoms. The χ2 test and decision tree modeling analysis were performed to examine factors affecting adherence. A 5% level of statistical significance was used in the χ2 test. Results: Questionnaires with data on 479 patients were returned. The most common level of adherence was “take as instructed” (81.2%), followed by “forget once or twice a week” (10.2%). The χ2 test revealed that adherence was good if "key person" was professional caretaker (P = 0.004). Also, adherence was better if key person understood medication about dosage, P < 0.001; effect, P = 0.002; and general side effects,, P < 0.001. According to decision tree analysis, the key person had the strongest relationship with adherence. Conclusions: It was confirmed that the key person’s understanding of the medication and symptoms of cognitive impairment are related to adherence. In particular, it was suggested that there is a strong relationship between the key person and adherence and that factors related to adherence differ according to who the key person is. It is essential in the treatment of cognitive impairment to accurately identify the "key person", in order to provide better pharmaceutical care in community pharmacies

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Acceptability and Long‐Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers: I. Acceptability of Drug Treatment

Cited by 3 publications

References 12 publications

Occupational Health Services Improve Effective Coverage for Hypertension and Diabetes Mellitus at Japanese Companies

Occupational Health Services Improve Effective Coverage for Hypertension and Diabetes Mellitus at Japanese Companies

Acceptability and Long‐Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers

Factors Related to Medication Adherence of Cognitively Impaired Patients in Community Pharmacies

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