Acceptability of prenatal diagnosis and prenatal treatment of haemophilia using cell and gene therapies within US haemophilia community

Abstract

Background The overall burden of disease in persons with haemophilia continues to be high despite the latest advancements in therapeutics. Clinical trials testing prenatal treatments for several genetic disorders are underway or are recruiting subjects, attesting to the much‐needed change in paradigm of how patients with monogenic disorders can be treated. Here we investigate the overall attitude towards prenatal diagnosis, preferences on types of prenatal therapies for haemophilia, the level of 'acceptable' risk tolerated, and which social and moral pressures or disease personal experiences may predict willingness of individuals to consider foetal therapy in a future pregnancy. Results A multidisciplinary team designed the survey, and the study was carried out using REDCap, and publicized through the National Haemophilia Foundation. Subjects ≥18 years of age were eligible to participate in the study. We assessed participants’ attitudes towards prenatal therapy and their level of 'acceptable' risk towards the procedure and therapy. The survey was completed by 67 adults, the majority females. Respondents were willing to undergo prenatal diagnosis, and their main concerns related to the well‐being of the pregnant woman and the foetus regarding lasting therapeutic efficacy, side effects of the therapy, and procedural risks, but they were likely to accept a wide range of prenatal therapeutic options, particularly if the foetal therapy proved to be long‐lasting and safe. Conclusions These data demonstrate the willingness of persons with haemophilia, and the haemophilia community, to explore new treatment options beyond the currently offered approaches.

Carbon quantum dots in bioimaging and biomedicines

“…Gene therapy s the technique of modifying a person’s genes to treat or cure an illness ( Pham et al, 2023 ). Gene therapy is regarded as a long-term and potentially curable therapeutic method for a variety of disorders ( Dunbar et al, 2018 ).…”

“…In this technique, the vector with excellent efficiency of gene transfection can transfer genetic components within the cells. According to reports from the past few years, CQDs can be employed as gene nanocarriers that can be tracked via imaging ( Ghosh et al, 2019a ; Han and Na, 2019 ; Pham et al, 2023 ). Therefore, among various nanoparticles, CQDs take considerable attention in gene therapy as a non-viral vector.…”