Acceptance and Commitment Therapy and Drug Use: A Systematic Review

Maia, Mariana Fonseca Carvalho; Santos, Bruna Ferreira dos; Castro, Lorrainy Costa de; Vieira, Natália São Tiago; Silveira, Pollyanna Santos da

doi:10.1590/1982-4327e3136

Cited by 1 publication

(3 citation statements)

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“…Generally, these constructs are cultivated through mindfulness‐based interventions (MBIs), such as Acceptance Commitment Therapy (ACT) 114 . Several reviews posit that the therapeutic efficacy of MBIs and ACT is similar to conventional AUD treatments, 116,117 particularly due to decreases in mood‐related comorbidities and levels of perceived craving 116–119 . Accordingly, some authors posit that MBIs and ACT should be integrated with PAT due to potential synergistic effects 167–170 .…”

Section: Discussionmentioning

confidence: 99%

“… 114 Several reviews posit that the therapeutic efficacy of MBIs and ACT is similar to conventional AUD treatments, 116 , 117 particularly due to decreases in mood‐related comorbidities and levels of perceived craving. 116 , 117 , 118 , 119 Accordingly, some authors posit that MBIs and ACT should be integrated with PAT due to potential synergistic effects. 167 , 168 , 169 , 170 However, various scholars consider the Western implementation of MBIs to be inadequate due to its failure to integrate the fundamental and essential teachings of Buddhism from which mindfulness originated.…”

Section: Discussionmentioning

confidence: 99%

“… 99 , 100 Consistently, several reviews are beginning to demonstrate the therapeutic potential of mindfulness and psychological flexibility‐based interventions in the treatment of AUD, 116 , 117 particularly to reduce mood‐related comorbidities and levels of perceived craving. 116 , 117 , 118 , 119 …”

Section: Potential Therapeutic Mechanisms Of Action Of 5‐me...mentioning

confidence: 99%

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The potential of 5‐methoxy‐N,N‐dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action

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2024

Addiction Biology

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Alcohol use disorder (AUD) remains one of the most prevalent psychiatric disorders worldwide with high economic costs. Current treatment options show modest efficacy and relapse rates are high. Furthermore, there are increases in the treatment gap and few new medications have been approved in the past 20 years. Recently, psychedelic‐assisted therapy with psilocybin and lysergic acid diethylamide has garnered significant attention in the treatment of AUD. Yet, they require significant amounts of therapist input due to prolonged subjective effects (~4–12 h) leading to high costs and impeding implementation. Accordingly, there is an increasing interest in the rapid and short‐acting psychedelic 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT). This paper offers a first look at potential therapeutic mechanisms for AUD by reviewing the current literature on 5‐MeO‐DMT. Primarily, 5‐MeO‐DMT is able to induce mystical experiences and ego‐dissolution together with increases in psychological flexibility and mindfulness. This could decrease AUD symptoms through the alleviation of psychiatric mood‐related comorbidities consistent with the negative reinforcement and self‐medication paradigms. In addition, preliminary evidence indicates that 5‐MeO‐DMT modulates neural oscillations that might subserve ego‐dissolution (increases in gamma), psychological flexibility and mindfulness (increases in theta), and the reorganization of executive control networks (increases in coherence across frequencies) that could improve emotion regulation and inhibition. Finally, animal studies show that 5‐MeO‐DMT is characterized by neuroplasticity, anti‐inflammation, 5‐HT2A receptor agonism, and downregulation of metabotropic glutamate receptor 5 with clinical implications for AUD and psychiatric mood‐related comorbidities. The paper concludes with several recommendations for future research to establish the purported therapeutic mechanisms of action.

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