Acceptance of pregnant women's vaccination against pertussis among French women and health professionals: PREVACOQ-1 and -2 studies

Barriers and Facilitators Associated With Vaccine Acceptance and Uptake Among Pregnant Women in High Income Countries: A Mini-Review

“…Knowledge of availability of influenza and pertussis vaccination in pregnancy is a pre-requisite for women to decide to vaccinate or not, and for a high proportion of women such knowledge is only gained when they are offered vaccination by an HCP. Consistent with previous findings (13), receiving a HCP recommendation was a main facilitator of vaccine uptake among pregnant women in recent studies, and its absence was the preeminent barrier reported among unvaccinated women (18,20,21,25,(28)(29)(30)(31). To illustrate, in an Italian survey 62% of vaccinated women said that HCP recommendation was the main facilitator of vaccination, whilst 81% of unvaccinated women reported no HCP recommendation as the main barrier experienced (21), while influenza vaccination uptake was 47% in women who reported being recommended to vaccinate by a HCP versus 3% in those who did not in a French study (17).…”

“…For maternal influenza vaccination the highest uptakes of 78% and 76%, were reported among 984 women in a US study and 101 women in a New Zealand study (14,15), with a Spanish study reporting 62% uptake among 683 women (16). Two large studies from France with 2045 and 1194 women reported uptakes of 36% and 22% respectively (17,18), with uptake of 45% among 823 women in Belgium (19) and 16.2% among 197 women in Greece (20). The lowest coverage was found in a study of 743 women in Italy at 6.5% (21).…”

“…Studies reported that pregnant women obtained information on vaccines from the media, family and friends, plus HCPs. The latter were the most common source in both a large French study of pertussis vaccination (18) and a study in New Zealand addressing influenza vaccine uptake (14). The importance of family, friends and the media as information sources among unvaccinated women varied by setting: in the New Zealand study, 20-25% cited these as having influenced their decision (14), whilst fewer than 5% of pregnant women intending not to be vaccinated in a UK study cited concerns about information in the media or the influence of family and friends as a reason (24).…”

“…Recent studies have shown sometimes significant knowledge gaps among HCPs regarding maternal immunization (18,27,33). Confidence to advise pregnant women also differed by profession and experience; e.g.…”

“…Perception of susceptibility and severity are constructs that influence health behaviors according to the Health Belief Model. Lefebvre and colleagues in a French study reported that women who perceived risk of acquisition of pertussis to be non-existent or low were significantly less likely to accept vaccination than those who perceived risk to be high (adjusted OR 0.44 [0.31,0.62]) (18). Similarly, in the Taiwanese study discussed above, 18% of women declining pertussis vaccination reported that the main factor in their decision was their belief that pertussis is not a severe disease in newborn infants; conversely, multivariable analysis showed that rating pertussis among young infants as highly severe was significantly associated with acceptance of the vaccine (22).…”