Due to the argued benefits of passenger comfort, cost savings, and road safety, the bus sector is showing increasing interest in advanced driver-assistance systems (ADAS). Despite this growth of interest in ADAS and the fact that work tasks are sometimes complicated (especially docking at bus-stops which may occur several hundred times per shift), there has been little research into ADAS in buses. Therefore, the aim of this study was to develop further knowledge of how professional bus drivers experience and accept an ADAS which can help them dock at bus-stops. The study was conducted on a public route in an industrial area with five different bus-stops. Ten professional bus drivers got to use a narrow navigation system (NNS) that could dock automatically at bus-stops. The participants’ experience and acceptance were investigated using objective as well as subjective data (during and after the test-drive) and data were collected using interviews, questionnaires, and video recordings. The participants indicated high levels of trust in and acceptance of the NNS and felt that it had multiple benefits in terms of cognitive and physical ergonomics, safety, and comfort. However, the relatively slow docking process (which was deemed comfortable) was also expected to negatively affect, e.g., timetabling, possibly resulting in high stress levels. Therefore, when investigating users’ acceptance of ADAS in a work context, it is important to consider acceptance in terms of the operation, use, and work system levels and how those levels interact and affect each other.