“…After this, a series of palladium-catalyzed ring-opening reactions of gem-difluorinated cyclopropanes were developed rapidly. The cross-coupling reactions of gem-difluorinated cyclopropanes with nucleophiles such as organoboronic acids 7 , terminal alkynes 8 , or borylalkenyl nucleophiles generated in situ from internal alkynes and B 2 pin 2 in the presence of copper complex as a co-catalyst, 9 were successively developed by the same group in 2019, 2020, and 2021, respectively (Schemes 2a-c). At the same time, Zhang and co-workers developed a palladium-catalyzed crosscoupling of gem-difluorinated cyclopropanes with arylsulfinates to synthesize 2-fluoroallylic sulfones (Scheme 2d), 10 and the Lin group reported an allylation/dearomatization reaction of -naphthols/indoles by using gem-difluorinated cyclopropanes as allyl sources under palladium catalysis (Scheme 2e).…”