Access to (E)-N′-benzylidene-N-(2-(phenylsulfonyl)ethyl)acetohydrazide via C(sp²)−H activation and reduction of (E)-N′-benzylideneacetohydrazide with (vinylsulfonyl)benzene

Abstract

A novel route for C(sp3)-N bond formation via C(sp2)−H activation/reduction by metal-free which uses ( E)- N′-benzylideneacetohydrazide and (vinylsulfonyl)benzene to synthesize derivatives of ( E)- N′-benzylidene- N-(2-(phenylsulfonyl)ethyl)acetohydrazide has been reported. This methodology features good functional group tolerance and convenient operation. In addition, it uses inexpensive and insensitive chemical reagents as raw materials and provides an atom- and efficient method for the preparation of ( E)- N′-benzylidene- N-(2-(phenylsulfonyl)ethyl)acetohydrazides.